Construction of a fluorescent probe with large stokes shift and deep red emission for sensing of the viscosity in hyperglycemic mice

被引：30

作者：

Liu, Yongyuan ^{[1
]}

Ma, Yanyan ^{[2
]}

Gao, Wenjie ^{[1
]}

Ma, Shihan ^{[1
]}

Lin, Weiying ^{[1
,3
]}

机构：

[1] Univ Jinan, Sch Chem & Chem Engn, Sch Mat Sci & Engn, Inst Fluorescent Probes Biol Imaging, Jinan 250022, Shandong, Peoples R China

[2] Qilu Univ Technol, Natl Engn & Technol Res Ctr Marine Monitoring Equ, Shandong Prov Key Lab Marine Monitoring Instrumen, Inst Oceanog Instrumentat,Shandong Acad Sci, 37 Miaoling Rd, Qingdao 266061, Peoples R China

[3] Guangxi Univ, Sch Chem & Chem Engn, Inst Opt Mat & Chem Biol, Guangxi Key Lab Electrochem Energy Mat, Nanning 530004, Guangxi, Peoples R China

来源：

DYES AND PIGMENTS | 2021年 / 195卷

关键词：

Viscosity; Fluorescence imaging; Hyperglycemia; Fluorescent probe; HYDROGEN-PEROXIDE; MOLECULAR ROTOR; MITOCHONDRIAL VISCOSITY; ALZHEIMERS-DISEASE; CELLS; SENSOR;

D O I：

10.1016/j.dyepig.2021.109674

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The detection of viscosity levels in biological systems is of great significance for the research of many diseases. Herein, we constructed a new viscosity probe ND-1 with large Stokes shift (>160 nm) and deep red emission (624 nm). Utilizing its excellent fluorescence performances, the unique probe ND-1 can not only detect the viscosity changes in living cells, zebrafish and tumor mice, but also successfully observe the variation of viscosity in acute hyperglycemia mice for the first time. It is expected that this work may help to promote the progress of related biomedical research and provide a potential tool for the detection and research of viscosity related diseases.

引用

页数：8

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