Brain-immune interactions and disease susceptibility

被引：93

作者：

Marques-Deak, A

Cizza, G

Sternberg, E

机构：

[1] NIMH, Sect Neuroendocrine Immunol & Behav, Integrat Neural Immune Program, NIH, Bethesda, MD 20892 USA

[2] NIDDKD, Ctr Endocrinol Branch, NIH, Bethesda, MD 20892 USA

来源：

MOLECULAR PSYCHIATRY | 2005年 / 10卷 / 03期

关键词：

neuroendocrine; depression; autoimmune disease; osteoporosis;

D O I：

10.1038/sj.mp.4001643

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Many studies have established the routes by which the immune and central nervous (CNS) systems communicate. This network of connections permits the CNS to regulate the immune system through both neuroendocrine and neuronal pathways. In turn, the immune system signals the CNS through neuronal and humoral routes, via immune mediators and cytokines. This regulatory system between the immune system and CNS plays an important role in susceptibility and resistance to autoimmune, inflammatory, infectious and allergic diseases. This review focuses on the regulation of the immune system via the neuroendocrine system, and underlines the link between neuroendocrine dysregulation and development of major depressive disorders, autoimmune diseases and osteoporosis.

引用

页码：239 / 250

页数：12

共 243 条

[71] Diurnal activity and pulsatility of the hypothalamus-pituitary-adrenal system in male depressed patients and healthy controls [J].