A Rare Case of Non-Hodgkins B-cell Lymphoma in a Psoriatic Patient:A Case Report and Literature Review

被引：0

作者：

Gattu, Shilpa ^{[1
]}

Becker, Emily M. ^{[2
]}

Koo, John Y. M. ^{[2
,3
]}

机构：

[1] Harbor UCLA Med Ctr, Torrance, CA 90509 USA

[2] Univ Texas San Antonio, Ctr Sci, Div Dermatol, San Antonio, TX USA

[3] Univ Calif San Francisco, Dept Dermatol, San Francisco, CA 94118 USA

来源：

JOURNAL OF DRUGS IN DERMATOLOGY | 2010年 / 9卷 / 10期

关键词：

RHEUMATOID-ARTHRITIS; METHOTREXATE THERAPY; LONG-TERM; LYMPHOPROLIFERATIVE DISORDERS; CYCLOSPORINE THERAPY; DOUBLE-BLIND; CANCER-RISK; TRANSPLANTATION; DISEASE; COHORT;

D O I：

暂无

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Cyclosporine has been shown to increase the risk of lymphoma when used in organ transplant patients; however, studies have failed to demonstrate an increased risk of lymphoma when used at lower dermatologic doses for psoriasis. The authors present a case of solid B-cell lymphoma occurring in a psoriasis patient with a history of intermittent exposure to high-dose methotrexate, followed by low-dose cyclosporine for two years and subsequently transitioned to treatment with adalimumab. Methotrexate, cyclosporine and adalimumab are each effective treatments for psoriasis. However, when faced with an interplay of several factors, closer surveillance for malignancy is warranted than that which is currently considered for monotherapy.

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页码：1277 / 1281

页数：5

相关论文

共 40 条

[1] Disease activity and risk of lymphoma in patients with rheumatoid arthritis:: nested case-control study [J].

Baecklund, E ;

Ekbom, A ;

Sparén, P ;

Feltelius, N ;

Klareskog, L .

BRITISH MEDICAL JOURNAL, 1998, 317 (7152) :180-181

[2] IS METHOTREXATE THERAPY FOR PSORIASIS CARCINOGENIC - MODIFIED RETROSPECTIVE PROSPECTIVE ANALYSIS [J].

BAILIN, PL ;

TINDALL, JP ;

ROENIGK, HH ;

HOGAN, MD .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1975, 232 (04) :359-362

[3]

Cliff S, 1999, BRIT J DERMATOL, V140, P763

[4] Primary cutaneous CD30+ large T-cell lymphoma in a patient with psoriasis treated with cyclosporine [J].

Corazza, M ;

Zampino, MR ;

Montanari, A ;

Altieri, E ;

Virgili, A .

DERMATOLOGY, 2003, 206 (04) :330-333

[5] CYCLOSPORINE IMPROVES PSORIASIS IN A DOUBLE-BLIND-STUDY [J].

ELLIS, CN ;

GORSULOWSKY, DC ;

HAMILTON, TA ;

BILLINGS, JK ;

BROWN, MD ;

HEADINGTON, JT ;

COOPER, KD ;

BAADSGAARD, O ;

DUELL, EA ;

ANNESLEY, TM ;

TURCOTTE, JG ;

VOORHEES, JJ .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1986, 256 (22) :3110-3116

[6]

Fozza C, 2005, EUR J DERMATOL, V15, P271

[7] Lymphoma rates are low but increased in patients with psoriasis - Results from a population-based cohort study in the United Kingdom [J].

Gelfand, JM ;

Berlin, J ;

Van Voorhecs, A ;

Margolis, DJ .

ARCHIVES OF DERMATOLOGY, 2003, 139 (11) :1425-1429

[8] Clinical response to alimumab treatment in patients with moderate to severe psoriasis: Double-blind, randomized controlled trial and open-label extension study [J].

Gordon, Kenneth B. ;

Langley, Richard G. ;

Leonardi, Craig ;

Toth, Darryl ;

Menter, M. Alan ;

Kang, Sewon ;

Heffernan, Michael ;

Miller, Bruce ;

Hamlin, Regina ;

Lim, Liberata ;

Zhong, Jianhua ;

Hoffman, Rebecca ;

Okun, Martin M. .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2006, 55 (04) :598-606

[9] CLEARANCE OF PSORIASIS WITH LOW-DOSE CYCLOSPORINE [J].

GRIFFITHS, CEM ;

POWLES, AV ;

LEONARD, JN ;

FRY, L ;

BAKER, BS ;

VALDIMARSSON, H .

BRITISH MEDICAL JOURNAL, 1986, 293 (6549) :731-732

[10] Psoriasis, its treatment, and cancer in a cohort of finnish patients [J].

Hannuksela-Svahn, A ;

Pukkala, E ;

Läärä, E ;

Poikolainen, K ;

Karvonen, J .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2000, 114 (03) :587-590

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