Typical CBFβ/MYH11 fusion due to insertion of the 3′-MYH11 gene into 16q22 in acute monocytic leukemia with normal chromosomes 16 and trisomies 8 and 22

被引：10
作者：
Aventín, A [1 ]
La Starza, R
Nomdedéu, J
Brunet, S
Sierra, J
Mecucci, C
机构：
[1] Univ Hosp St Pau, Dept Hematol, Barcelona, Spain
[2] Univ Perugia, Hematol & Bone Marrow Transplantat Unit, I-06100 Perugia, Italy
来源：
CANCER GENETICS AND CYTOGENETICS | 2000年 / 123卷 / 02期
关键词：
D O I：
10.1016/S0165-4608(00)00321-6
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
In a case of acute monocytic leukemia, M5a according to the FAB classification, with a 48,XY,+8,+22 karyotype, amplification of the CBF beta /MYH11 fusion transcript type A was detected by reverse transcriptase-polymerase chain reaction (RT-PCR). Fluorescence in situ hybridization (FISH) using an appropriate panel of DNA probes showed that insertion of the 3'-MYH11 within the CBF beta gene on chromosome 16q22 was the mechanism producing the same molecular rearrangement as in typical inv(16)(p13q22)/t(16;16)(p13;q22). (C) 2000 Elsevier Science Inc. All rights reserved.
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页码：137 / 139
页数：3
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