Typical CBFβ/MYH11 fusion due to insertion of the 3′-MYH11 gene into 16q22 in acute monocytic leukemia with normal chromosomes 16 and trisomies 8 and 22

被引：10

作者：

Aventín, A ^{[1
]}

La Starza, R

Nomdedéu, J

Brunet, S

Sierra, J

Mecucci, C

机构：

[1] Univ Hosp St Pau, Dept Hematol, Barcelona, Spain

[2] Univ Perugia, Hematol & Bone Marrow Transplantat Unit, I-06100 Perugia, Italy

来源：

CANCER GENETICS AND CYTOGENETICS | 2000年 / 123卷 / 02期

关键词：

D O I：

10.1016/S0165-4608(00)00321-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In a case of acute monocytic leukemia, M5a according to the FAB classification, with a 48,XY,+8,+22 karyotype, amplification of the CBF beta /MYH11 fusion transcript type A was detected by reverse transcriptase-polymerase chain reaction (RT-PCR). Fluorescence in situ hybridization (FISH) using an appropriate panel of DNA probes showed that insertion of the 3'-MYH11 within the CBF beta gene on chromosome 16q22 was the mechanism producing the same molecular rearrangement as in typical inv(16)(p13q22)/t(16;16)(p13;q22). (C) 2000 Elsevier Science Inc. All rights reserved.

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页码：137 / 139

页数：3

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