Integrase-defective lentiviral-vector-based vaccine: a new vector for induction of T cell immunity

被引：29

作者：

Negri, Donatella R. M. ^{[1
]}

Michelini, Zuleika ^{[2
]}

Bona, Roberta ^{[2
]}

Blasi, Maria ^{[3
]}

Filati, Piero ^{[2
]}

Leone, Pasqualina ^{[2
]}

Rossi, Alessandra ^{[1
]}

Franco, Marina ^{[2
]}

Cara, Andrea ^{[2
]}

机构：

[1] Ist Super Sanita, Dept Infect Parasit & Immune Mediated Dis, I-00161 Rome, Italy

[2] Ist Super Sanita, Dept Therapeut Res & Med Evaluat, I-00161 Rome, Italy

[3] Ist Super Sanita, Dept Cell Biol & Neurosci, I-00161 Rome, Italy

来源：

EXPERT OPINION ON BIOLOGICAL THERAPY | 2011年 / 11卷 / 06期

关键词：

HIV-1; integrase; integrase inhibitors; lentiviral vector; T cell immunity; vaccine; SIMIAN IMMUNODEFICIENCY VIRUS; GENE-TRANSFER; DENDRITIC CELLS; HIV-INTEGRASE; IN-VIVO; PERSISTENT TRANSCRIPTION; INTRANASAL DELIVERY; NONDIVIDING CELLS; EPISOMAL VECTORS; NASAL EPITHELIA;

D O I：

10.1517/14712598.2011.571670

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Areas covered: In this review we describe the development and application of IDLV for vaccination. IDLV are turning out to be a new class of vectors endowed with peculiar characteristics, setting them apart from the parental integration-competent lentiviral vectors. Recent data suggest that IDLV are able to induce strong antigen-specific immune responses in terms of quantity, persistence and quality of CD8<SU++</SU T cell response following a single immunization in mice. Expert opinion: IDLV are a recent acquisition in the field of genetic immunization, thus allowing for the opportunity of further upgrading, including increasing antigen expression and potency of immune response. Based on recent reports showing the potential of IDLV for immunization in mouse models, further development and validation of IDLV, including comparison with other vaccine protocols and use in non-human primate models, are warranted.

引用

页码：739 / 750

页数：12

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