Biomarker Associations in Delayed Cerebral Ischemia after Aneurysmal Subarachnoid Hemorrhage

被引：7

作者：

Spantler, Dora ^{[1
,2
]}

Molnar, Tihamer ^{[1
]}

Simon, Diana ^{[3
]}

Berki, Timea ^{[3
]}

Buki, Andras ^{[4
]}

Schwarcz, Attila ^{[2
]}

Csecsei, Peter ^{[2
]}

机构：

[1] Univ Pecs, Dept Anaesthesiol & Intens Care, Med Sch, H-7624 Pecs, Hungary

[2] Univ Pecs, Med Sch, Dept Neurosurg, H-7624 Pecs, Hungary

[3] Univ Pecs, Med Sch, Dept Immunol & Biotechnol, H-7624 Pecs, Hungary

[4] Orebro Univ, Fac Med & Hlth, Dept Neurosurg, S-70281 Orebro, Sweden

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 15期

关键词：

aneurysmal subarachnoid hemorrhage; delayed cerebral ischemia; functional outcome; MCP-3; CX3CL1; IP-10; MONOCYTE CHEMOTACTIC PROTEIN-3; TRANSCRANIAL DOPPLER; BRAIN-INJURY; VASOSPASM; FRACTALKINE; EXPRESSION; PREVENTION; CYTOKINES; RECEPTOR; TRIALS;

D O I：

10.3390/ijms23158789

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The prognosis for patients with aneurysmal subarachnoid hemorrhage (aSAH) is heavily influenced by the development of delayed cerebral ischemia (DCI), but the adequate and effective therapy of DCI to this day has not been resolved. Multiplex serum biomarker studies may help to understand the pathophysiological processes underlying DCI. Samples were collected from patients with aSAH at two time points: (1) 24 h (Day 1) and (2) 5-7 days after ictus. Serum concentrations of eotaxin, FGF-2, FLT-3L, CX3CL1, Il-1b, IL-4, IP-10, MCP3, and MIP-1b were determined using a customized MILLIPLEX Human Cytokine/Chemokine/Growth Factor Panel A multiplex assay. The functional outcome was defined by the modified Rankin scale (favorable: 0-2, unfavorable: 3-6) measured on the 30th day after aSAH. One-hundred and twelve patients with aSAH were included in this study. The median level of CX3CL1 and MCP-3 measured on Days 5-7 were significantly higher in patients with DCI compared with those without DCI (CX3CL1: with DCI: 110.5 pg/mL, IQR: 82-201 vs. without DCI: 82.6, 58-119, p = 0.036; and MCP-3: with DCI: 22 pg/mL (0-32) vs. without DCI: 0 (0-11), p < 0.001). IP-10, MCP-3, and MIP-1b also showed significant associations with the functional outcome after aSAH. MCP-3 and CX3CL1 may play a role in the pathophysiology of DCI.

引用

页数：15

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