Balancing diversity and tolerance: lessons from patients with systemic lupus erythematosus

被引：43

作者：

Jacobi, AM

Diamond, B ^{[1
]}

机构：

[1] Columbia Univ, Med Ctr, Dept Med, New York, NY 10032 USA

[2] Columbia Univ, Med Ctr, Dept Microbiol, New York, NY 10032 USA

[3] Charite Univ Hosp, Dept Rheumatol & Clin Immunol, D-10117 Berlin, Germany

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2005年 / 202卷 / 03期

关键词：

D O I：

10.1084/jem.20050221

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The autoimmune disease systemic lupus erythematosus (SLE) is caused by a failure of B cell tolerance. Recent studies in mouse models of SLE have identified several distinct tolerance checkpoints that must each function appropriately to protect against disease. However, studies of B cell repertoire selection in humans are essential to understand which checkpoints are defective in human autoimmune diseases.

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页码：341 / 344

页数：4

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