The family of iron responsive RNA structures regulated by changes in cellular iron and oxygen

被引：82
作者：
Leipuviene, R.
Theil, E. C.
机构：
[1] CHORI, Ctr BioIron, Oakland, CA 94609 USA
[2] Univ Calif Berkeley, Dept Nutr Sci & Toxicol, Berkeley, CA 94720 USA
来源：
CELLULAR AND MOLECULAR LIFE SCIENCES | 2007年 / 64卷 / 22期
关键词：
iron; oxygen; mRNA regulation; IRE/IRP system; iron regulatory protein; iron-responsive element;
D O I：
10.1007/s00018-007-7198-4
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The life of aerobes is dependent on iron and oxygen for efficient bioenergetics. Due to potential risks associated with iron/oxygen chemistry, iron acquisition, concentration, storage, utilization, and efflux are tightly regulated in the cell. A central role in regulating iron/oxygen chemistry in animals is played by mRNA translation or turnover via the iron responsive element (IRE)/iron regulatory protein (IRP) system. The IRE family is composed of threedimensional RNA structures located in 3' or 5' untranslated regions of mRNA. To date, there are 11 different IRE mRNAs in the family, regulated through translation initiation or mRNA stability. Iron or oxidant stimuli induce a set of graded responses related to mRNA-specific IRE substructures, indicated by differential. responses to iron in vivo and binding IRPs in vitro. Molecular effects of phosphorylation, iron and oxygen remain to be added to the structural information of the IRE-RNA and IRP repressor in the regulatory complex.
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收藏
页码：2945 / 2955
页数：11
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