The family of iron responsive RNA structures regulated by changes in cellular iron and oxygen

被引：82
作者：
Leipuviene, R.
Theil, E. C.
机构：
[1] CHORI, Ctr BioIron, Oakland, CA 94609 USA
[2] Univ Calif Berkeley, Dept Nutr Sci & Toxicol, Berkeley, CA 94720 USA
来源：
CELLULAR AND MOLECULAR LIFE SCIENCES | 2007年 / 64卷 / 22期
关键词：
iron; oxygen; mRNA regulation; IRE/IRP system; iron regulatory protein; iron-responsive element;
D O I：
10.1007/s00018-007-7198-4
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The life of aerobes is dependent on iron and oxygen for efficient bioenergetics. Due to potential risks associated with iron/oxygen chemistry, iron acquisition, concentration, storage, utilization, and efflux are tightly regulated in the cell. A central role in regulating iron/oxygen chemistry in animals is played by mRNA translation or turnover via the iron responsive element (IRE)/iron regulatory protein (IRP) system. The IRE family is composed of threedimensional RNA structures located in 3' or 5' untranslated regions of mRNA. To date, there are 11 different IRE mRNAs in the family, regulated through translation initiation or mRNA stability. Iron or oxidant stimuli induce a set of graded responses related to mRNA-specific IRE substructures, indicated by differential. responses to iron in vivo and binding IRPs in vitro. Molecular effects of phosphorylation, iron and oxygen remain to be added to the structural information of the IRE-RNA and IRP repressor in the regulatory complex.
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收藏
页码：2945 / 2955
页数：11
相关论文
共 133 条
[1]   Structure and dynamics of the iron responsive element RNA: Implications for binding of the RNA by iron regulatory binding proteins [J].
Addess, KJ ;
Basilion, JP ;
Klausner, RD ;
Rouault, TA ;
Pardi, A .
JOURNAL OF MOLECULAR BIOLOGY, 1997, 274 (01) :72-83
[2]   Bacillus subtilis aconitase is an RNA-binding protein [J].
Alén, C ;
Sonenshein, AL .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (18) :10412-10417
[3]   Clinical severity and thermodynamic effects of iron-responsive element mutations in hereditary hyperferritinemia-cataract syndrome [J].
Allerson, CR ;
Cazzola, M ;
Rouault, TA .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (37) :26439-26447
[4]   Iron homeostasis [J].
Andrews, Nancy C. ;
Schmidt, Paul J. .
ANNUAL REVIEW OF PHYSIOLOGY, 2007, 69 :69-85
[5]   Ferritin, iron homeostasis, and oxidative damage [J].
Arosio, P ;
Levi, S .
FREE RADICAL BIOLOGY AND MEDICINE, 2002, 33 (04) :457-463
[6]   IRON REGULATES FERRITIN MESSENGER-RNA TRANSLATION THROUGH A SEGMENT OF ITS 5' UNTRANSLATED REGION [J].
AZIZ, N ;
MUNRO, HN .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (23) :8478-8482
[7]  
BETTANY AJE, 1992, J BIOL CHEM, V267, P16531
[8]  
Beuning PJ, 1999, BIOPOLYMERS, V52, P1
[9]   EVIDENCE THAT THE PATHWAY OF TRANSFERRIN RECEPTOR MESSENGER-RNA DEGRADATION INVOLVES AN ENDONUCLEOLYTIC CLEAVAGE WITHIN THE 3' UTR AND DOES NOT INVOLVE POLY(A) TAIL SHORTENING [J].
BINDER, R ;
HOROWITZ, JA ;
BASILION, JP ;
KOELLER, DM ;
KLAUSNER, RD ;
HARFORD, JB .
EMBO JOURNAL, 1994, 13 (08) :1969-1980
[10]   Structural changes associated with switching activities of human iron regulatory protein 1 [J].
Brazzolotto, X ;
Timmins, P ;
Dupont, Y ;
Moulis, JM .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (14) :11995-12000
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