Gomisin N from Schisandra chinensis Ameliorates Lipid Accumulation and Induces a Brown Fat-Like Phenotype through AMP-Activated Protein Kinase in 3T3-L1 Adipocytes

被引:17
|
作者
Lee, Kippeum [1 ]
Lee, Yeon-Joo [1 ]
Kim, Kui-Jin [1 ]
Chei, Sungwoo [1 ]
Jin, Heegu [1 ]
Oh, Hyun-Ji [1 ]
Lee, Boo-Yong [1 ]
机构
[1] CHA Univ, Coll Life Sci, Dept Food Sci & Biotechnol, Seongnam 13488, Kyonggi Do, South Korea
关键词
gomisin N; 3T3-L1; lipid accumulation; browning; obesity; ADIPOSE-TISSUE; ENERGY-METABOLISM; WHITE; ALPHA; LIPOPOLYSACCHARIDE; DYSFUNCTION; EXPRESSION; LIGNANS; PRDM16; CELLS;
D O I
10.3390/ijms21062153
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Obesity results from an imbalance between energy intake and energy expenditure, in which excess fat is stored as triglycerides (TGs) in white adipocytes. Recent studies have explored the anti-obesity effects of certain edible phytochemicals, which suppress TG accumulation and stimulate a brown adipocyte-like phenotype in white adipocytes. Gomisin N (GN) is an important bioactive component of Schisandra chinensis, a woody plant endemic to Asia. GN has antioxidant, anti-inflammatory and hepatoprotective effects in vivo and in vitro. However, the anti-obesity effects of GN in lipid metabolism and adipocyte browning have not yet been investigated. In the present study, we aimed to determine whether GN suppresses lipid accumulation and regulates energy metabolism, potentially via AMP-activated protein kinase (AMPK), in 3T3-L1 adipocytes. Our findings demonstrate that GN inhibited adipogenesis and lipogenesis in adipocyte differentiation. Also, GN not only increased the expression of thermogenic factors, including uncoupling protein 1 (UCP1), but also enhanced fatty acid oxidation (FAO) in 3T3-L1 cells. Therefore, GN may have a therapeutic benefit as a promising natural agent to combat obesity.
引用
收藏
页数:14
相关论文
共 50 条
  • [21] Resveratrol induces brown-like adipocyte formation in white fat through activation of AMP-activated protein kinase (AMPK) α1
    Wang, S.
    Liang, X.
    Yang, Q.
    Fu, X.
    Rogers, C. J.
    Zhu, M.
    Rodgers, B. D.
    Jiang, Q.
    Dodson, M. V.
    Du, M.
    INTERNATIONAL JOURNAL OF OBESITY, 2015, 39 (06) : 967 - 976
  • [22] CHROMIUM PICOLINATE INHIBITS RESISTIN SECRETION IN INSULIN-RESISTANT 3T3-L1 ADIPOCYTES VIA ACTIVATION OF AMP-ACTIVATED PROTEIN KINASE
    Wang, Yi-Qun
    Dong, Yi
    Yao, Ming-Hui
    CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2009, 36 (08): : 843 - 849
  • [23] Resveratrol induces brown-like adipocyte formation in white fat through activation of AMP-activated protein kinase (AMPK) α1
    S Wang
    X Liang
    Q Yang
    X Fu
    C J Rogers
    M Zhu
    B D Rodgers
    Q Jiang
    M V Dodson
    M Du
    International Journal of Obesity, 2015, 39 : 967 - 976
  • [24] Inhibitory Mechanism of TNF-α-Induced Serine Phosphorylation of IRS-1 Mediated by AMP-Activated Protein Kinase in 3T3-L1 Adipocytes
    Satoh, Kumi
    Shibata, Tomohito
    Takaguri, Akira
    Kano, Seiichiro
    Ichihara, Kazuo
    DIABETES, 2010, 59 : A381 - A381
  • [25] Anti-Obesity Effect of α-Cubebenol Isolated from Schisandra chinensis in 3T3-L1 Adipocytes
    Lee, Su Jin
    Kim, Ji Eun
    Choi, Yun Ju
    Gong, Jeong Eun
    Jin, You Jeong
    Lee, Da Woon
    Choi, Young Whan
    Hwang, Dae Youn
    BIOMOLECULES, 2021, 11 (11)
  • [26] Short chain fatty acids increase fat oxidation and promote browning through 03-adrenergic receptor/AMP-activated protein kinase ? signaling pathway in 3T3-L1 adipocytes
    Zhang, Wenkai
    Kong, Li
    Zhong, Zhen
    Lin, Lezhen
    Li, Jingen
    Zheng, Guodong
    JOURNAL OF FUNCTIONAL FOODS, 2023, 103
  • [27] Trans-Cinnamic Acid Increases Adiponectin and the Phosphorylation of AMP-Activated Protein Kinase through G-Protein-Coupled Receptor Signaling in 3T3-L1 Adipocytes
    Kopp, Christina
    Singh, Shiva P.
    Regenhard, Petra
    Mueller, Ute
    Sauerwein, Helga
    Mielenz, Manfred
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2014, 15 (02) : 2906 - 2915
  • [28] Effects of an AMP-activated protein kinase inhibitor, compound C, on adipogenic differentiation of 3T3-L1 cells
    Gao, Ye
    Zhou, Yi
    Xu, Aimin
    Wu, Donghai
    BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2008, 31 (09) : 1716 - 1722
  • [29] Inhibitory Effects of A-769662, a Novel Activator of AMP-Activated Protein Kinase, on 3T3-L1 Adipogenesis
    Zhou, Yi
    Wang, Dongye
    Zhu, Qiang
    Gao, Xuefei
    Yang, Song
    Xu, Aimin
    Wu, Donghai
    BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2009, 32 (06) : 993 - 998
  • [30] Smilax china Polyphenols Stimulate Browning via β3-Adrenergic Receptor/AMP-Activated Protein Kinase α Signaling Pathway in 3T3-L1 Adipocytes
    Kong, Li
    Xu, Meng
    Yang, Licong
    Liu, Shanshan
    Zheng, Guodong
    AMERICAN JOURNAL OF CHINESE MEDICINE, 2022, 50 (05): : 1315 - 1329