Synthesis and biological evaluation of 3,5-diaryl isoxazoline/isoxazole linked 2, 3-dihydroquinazolinone hybrids as anticancer agents

被引：177

作者：

Kamal, Ahmed ^{[1
]}

Bharathi, E. Vijaya ^{[1
]}

Reddy, J. Surendranadha ^{[1
]}

Ramaiah, M. Janaki ^{[2
]}

Dastagiri, D. ^{[1
]}

Reddy, M. Kashi ^{[1
]}

Viswanath, A. ^{[1
]}

Reddy, T. Lakshminarayan ^{[2
]}

Shaik, T. Basha ^{[1
]}

Pushpavalli, S. N. C. V. L. ^{[2
]}

Bhadra, Manika Pal ^{[2
]}

机构：

[1] Indian Inst Chem Technol, Div Organ Chem, Hyderabad 500607, Andhra Pradesh, India

[2] Indian Inst Chem Technol, Biol Chem Lab, Hyderabad 500607, Andhra Pradesh, India

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2011年 / 46卷 / 02期

关键词：

3,5-Diaryl isoxazoline/isoxazole; 2,3-Dihydroquinazolinones; Cytotoxicity; Cell cycle effects; Tubulin depolymerization; TUBULIN POLYMERIZATION; COMBRETASTATIN A-4; DERIVATIVES; BINDING; POTENT; ANALOGS; CELLS; CYTOTOXICITY; INHIBITION; APOPTOSIS;

D O I：

10.1016/j.ejmech.2010.12.004

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of new 3,5-diaryl isoxazoline/isoxazole linked 2,3-dihydro quinazolinone hybrids with different linker architectures have been designed and synthesized. These compounds have been evaluated for their anticancer activity. One of the compounds 4c amongst this series has shown promising anticancer activity. Further some detailed biological assays relating to the cell cycle aspects and tubulin depolymerization activity have been examined with a view to understand the mechanism of action of this conjugate. (C) 2010 Elsevier Masson SAS. All rights reserved.

引用

页码：691 / 703

页数：13

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