Tumor-suppressive activity of 1,25-dihydroxyvitamin D3 against kidney cancer cells via up-regulation of FOXO3

被引：13

作者：

Lee, Jongsung ^{[1
]}

Park, See-Hyoung ^{[2
]}

机构：

[1] Sungkyunkwan Univ, Dept Genet Engn, Suwon, South Korea

[2] Hongik Univ, Dept Bio & Chem Engn, Sejong, South Korea

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2016年 / 80卷 / 10期

关键词：

tumor-suppressive; 1; 25-dihydroxyvitamin D3; kidney; cancer; FOXO3; VITAMIN-D-3 ANALOG EB1089; NCI-H929 MYELOMA CELLS; TRANSCRIPTION FACTORS; COLORECTAL-CANCER; OVARIAN-CANCER; RENAL-CANCER; D-RECEPTOR; IN-VITRO; APOPTOSIS; PROSTATE;

D O I：

10.1080/09168451.2016.1184561

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1,25-Dihydroxyvitamin D3 has been known to have the tumor-suppressive activity in various kinds of tumors. However, the exact effect and working mechanism of 1,25-dihydroxyvitamin D3 on the tumor-suppressive activity in human kidney cancer cells remains poorly understood. 1,25-Dihydroxyvitamin D3 has cytotoxicity to ACHN cells and inhibited ACHN cell proliferation compared to the vehicle control. 1,25-Dihydroxyvitamin D3 increased the expression of the cleaved PARP1, active Caspase3, Bax, and Bim but decreased the expression of Bcl2 in ACHN cells. Moreover, 1,25-dihydroxyvitamin D3 down-regulated the phosphorylated Akt and Erk which might lead to apoptosis through activation of FOXO3 in ACHN cells. Transfection of siRNA against FOXO3 attenuated the pro-apoptotic BimEL expression in ACHN cells treated with 1,25-dihydroxyvitamin D3. These results suggest that FOXO3 is involved in the apoptosis induced by 1,25-dihydroxyvitamin D3.

引用

页码：1947 / 1953

页数：7

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