Different Tumor Microenvironments Lead to Different Metabolic Phenotypes

被引：22
作者：
Antonio, Marjorie Justine [1 ]
Zhang, Cissy [1 ,2 ]
Le, Anne [3 ,4 ]
机构：
[1] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA
[2] Johns Hopkins Univ, Dept Biol, Krieger Sch Arts & Sci, Baltimore, MD 21218 USA
[3] Johns Hopkins Univ, Sch Med, Dept Pathol & Oncol, Baltimore, MD 21218 USA
[4] Johns Hopkins Univ, Whiting Sch Engn, Dept Chem & Biomol Engn, Baltimore, MD 21218 USA
来源：
HETEROGENEITY OF CANCER METABOLISM, 2ND EDITION | 2021年 / 1311卷
关键词：
Tumor microenvironments; Metabolic phenotypes; Fatty acid oxidation; Metabolic processes; Heterogeneity of cancer; FATTY-ACID OXIDATION; GLUTAMINE-METABOLISM; TRANSFORMED-CELLS; CANCER; SURVIVAL; HALLMARKS; HYPOXIA; GROWTH; METASTASIS; PATHWAYS;
D O I：
10.1007/978-3-030-65768-0_10
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
引用
收藏
页码：137 / 147
页数：11
相关论文
共 48 条
[1]   Hypoxia, lipids, and cancer: surviving the harsh tumor microenvironment [J].
Ackerman, Daniel ;
Simon, M. Celeste .
TRENDS IN CELL BIOLOGY, 2014, 24 (08) :472-478
[2]   Metabolic Symbiosis Enables Adaptive Resistance to Anti-angiogenic Therapy that Is Dependent on mTOR Signaling [J].
Allen, Elizabeth ;
Mieville, Pascal ;
Warren, Carmen M. ;
Saghafinia, Sadegh ;
Li, Leanne ;
Peng, Mei-Wen ;
Hanahan, Douglas .
CELL REPORTS, 2016, 15 (06) :1144-1160
[3]   Metabolic pathways promoting cancer cell survival and growth [J].
Boroughs, Lindsey K. ;
DeBerardinis, Ralph J. .
NATURE CELL BIOLOGY, 2015, 17 (04) :351-359
[4]   Glucose Metabolism in Cancer: The Warburg Effect and Beyond [J].
Bose, Sminu ;
Zhang, Cissy ;
Le, Anne .
HETEROGENEITY OF CANCER METABOLISM, 2ND EDITION, 2021, 1311 :3-15
[5]   Regulation of cancer cell metabolism [J].
Cairns, Rob A. ;
Harris, Isaac S. ;
Mak, Tak W. .
NATURE REVIEWS CANCER, 2011, 11 (02) :85-95
[6]   Pyruvate carboxylase is required for glutamine-independent growth of tumor cells [J].
Cheng, Tzuling ;
Sudderth, Jessica ;
Yang, Chendong ;
Mullen, Andrew R. ;
Jin, Eunsook S. ;
Mates, Jose M. ;
DeBerardinis, Ralph J. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (21) :8674-8679
[7]   Glucose Addiction of TSC Null Cells Is Caused by Failed mTORC1-Dependent Balancing of Metabolic Demand with Supply [J].
Choo, Andrew Y. ;
Kim, Sang Gyun ;
Heiden, Matthew G. Vander ;
Mahoney, Sarah J. ;
Vu, Hieu ;
Yoon, Sang-Oh ;
Cantley, Lewis C. ;
Blenis, John .
MOLECULAR CELL, 2010, 38 (04) :487-499
[8]   Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer [J].
Davidson, Shawn M. ;
Papagiannakopoulos, Thales ;
Olenchock, Benjamin A. ;
Heyman, Julia E. ;
Keibler, Mark A. ;
Luengo, Alba ;
Bauer, Matthew R. ;
Jha, Abhishek K. ;
O'Brien, James P. ;
Pierce, Kerry A. ;
Gui, Dan Y. ;
Sullivan, Lucas B. ;
Wasylenko, Thomas M. ;
Subbaraj, Lakshmipriya ;
Chin, Christopher R. ;
Stephanopolous, Gregory ;
Mott, Bryan T. ;
Jacks, Tyler ;
Clish, Clary B. ;
Heiden, Matthew G. Vander .
CELL METABOLISM, 2016, 23 (03) :517-528
[9]   Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis [J].
DeBerardinis, Ralph J. ;
Mancuso, Anthony ;
Daikhin, Evgueni ;
Nissim, Ilana ;
Yudkoff, Marc ;
Wehrli, Suzanne ;
Thompson, Craig B. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (49) :19345-19350
[10]   Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer [J].
Elgogary, Amira ;
Xu, Qingguo ;
Poore, Brad ;
Alt, Jesse ;
Zimmermann, Sarah C. ;
Zhao, Liang ;
Fu, Jie ;
Chen, Baiwei ;
Xia, Shiyu ;
Liu, Yanfei ;
Neisser, Marc ;
Nguyen, Christopher ;
Lee, Ramon ;
Park, Joshua K. ;
Reyes, Juvenal ;
Hartung, Thomas ;
Rojas, Camilo ;
Rais, Rana ;
Tsukamoto, Takashi ;
Semenza, Gregg L. ;
Hanes, Justin ;
Slusher, Barbara S. ;
Le, Anne .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016, 113 (36) :E5328-E5336
12345