Applying Next-Generation Sequencing Platforms for Pharmacogenomic Testing in Clinical Practice

被引：30

作者：

Tafazoli, Alireza ^{[1
,2
]}

Guchelaar, Henk-Jan ^{[3
,4
]}

Miltyk, Wojciech ^{[1
]}

Kretowski, Adam J. ^{[2
,5
]}

Swen, Jesse J. ^{[3
,4
]}

机构：

[1] Med Univ Bialystok, Fac Pharm, Dept Anal & Bioanal Med, Div Lab Med, Bialystok, Poland

[2] Med Univ Bialystok, Clin Res Ctr, Bialystok, Poland

[3] Leiden Univ, Dept Clin Pharm & Toxicol, Med Ctr, Leiden, Netherlands

[4] Leiden Network Personalized Therapeut, Leiden, Netherlands

[5] Med Univ Bialystok, Dept Endocrinol Diabetol & Internal Med, Bialystok, Poland

来源：

FRONTIERS IN PHARMACOLOGY | 2021年 / 12卷

基金：

欧盟地平线“2020”;

关键词：

pharmacogenomics; clinical implementation; next generation sequencing; clinical practice; PGx testing; IMPLEMENTATION CONSORTIUM; INCIDENTAL FINDINGS; CYP2D6; DRUG; GENOTYPE; CHALLENGES; EXOME; RECOMMENDATIONS; INFORMATION; MUTATIONS;

D O I：

10.3389/fphar.2021.693453

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Pharmacogenomics (PGx) studies the use of genetic data to optimize drug therapy. Numerous clinical centers have commenced implementing pharmacogenetic tests in clinical routines. Next-generation sequencing (NGS) technologies are emerging as a more comprehensive and time- and cost-effective approach in PGx. This review presents the main considerations for applying NGS in guiding drug treatment in clinical practice. It discusses both the advantages and the challenges of implementing NGS-based tests in PGx. Moreover, the limitations of each NGS platform are revealed, and the solutions for setting up and management of these technologies in clinical practice are addressed.

引用

页数：15

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