Applying Next-Generation Sequencing Platforms for Pharmacogenomic Testing in Clinical Practice

被引：34
作者：
Tafazoli, Alireza [1 ,2 ]
Guchelaar, Henk-Jan [3 ,4 ]
Miltyk, Wojciech [1 ]
Kretowski, Adam J. [2 ,5 ]
Swen, Jesse J. [3 ,4 ]
机构：
[1] Med Univ Bialystok, Fac Pharm, Dept Anal & Bioanal Med, Div Lab Med, Bialystok, Poland
[2] Med Univ Bialystok, Clin Res Ctr, Bialystok, Poland
[3] Leiden Univ, Dept Clin Pharm & Toxicol, Med Ctr, Leiden, Netherlands
[4] Leiden Network Personalized Therapeut, Leiden, Netherlands
[5] Med Univ Bialystok, Dept Endocrinol Diabetol & Internal Med, Bialystok, Poland
来源：
FRONTIERS IN PHARMACOLOGY | 2021年 / 12卷
基金：
欧盟地平线“2020”;
关键词：
pharmacogenomics; clinical implementation; next generation sequencing; clinical practice; PGx testing; IMPLEMENTATION CONSORTIUM; INCIDENTAL FINDINGS; CYP2D6; DRUG; GENOTYPE; CHALLENGES; EXOME; RECOMMENDATIONS; INFORMATION; MUTATIONS;
D O I：
10.3389/fphar.2021.693453
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Pharmacogenomics (PGx) studies the use of genetic data to optimize drug therapy. Numerous clinical centers have commenced implementing pharmacogenetic tests in clinical routines. Next-generation sequencing (NGS) technologies are emerging as a more comprehensive and time- and cost-effective approach in PGx. This review presents the main considerations for applying NGS in guiding drug treatment in clinical practice. It discusses both the advantages and the challenges of implementing NGS-based tests in PGx. Moreover, the limitations of each NGS platform are revealed, and the solutions for setting up and management of these technologies in clinical practice are addressed.
引用
收藏
页数：15
相关论文
共 97 条
[1]  
Ammar Ron, 2015, F1000Res, V4, P17, DOI 10.12688/f1000research.6037.2
[2]   The landscape of pharmacogenetic testing in a US managed care population [J].
Anderson, Heather D. ;
Crooks, Kristy R. ;
Kao, David P. ;
Aquilante, Christina L. .
GENETICS IN MEDICINE, 2020, 22 (07) :1247-1253
[3]   DMET™ (Drug Metabolism Enzymes and Transporters): a Pharmacogenomic platform for precision medicine [J].
Arbitrio, Mariamena ;
Di Martino, Maria Teresa ;
Scionti, Francesca ;
Agapito, Giuseppe ;
Guzzi, Pietro Hiram ;
Cannataro, Mario ;
Tassone, Pierfrancesco ;
Tagliaferri, Pierosandro .
ONCOTARGET, 2016, 7 (33) :54028-54050
[4]   Detecting AGG Interruptions in Male and Female FMR1 Premutation Carriers by Single-Molecule Sequencing [J].
Ardui, Simon ;
Race, Valerie ;
Zablotskaya, Alena ;
Hestand, Matthew S. ;
Van Esch, Hilde ;
Devriendt, Koenraad ;
Matthijs, Gert ;
Vermeesch, Joris R. .
HUMAN MUTATION, 2017, 38 (03) :324-331
[5]   PharmGKB: A worldwide resource for pharmacogenomic information [J].
Barbarino, Julia M. ;
Whirl-Carrillo, Michelle ;
Altman, Russ B. ;
Klein, Teri E. .
WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE, 2018, 10 (04)
[6]   PharmGKB summary: very important pharmacogene information for UGT1A1 [J].
Barbarino, Julia M. ;
Haidar, Cyrine E. ;
Klein, Teri E. ;
Altman, Russ B. .
PHARMACOGENETICS AND GENOMICS, 2014, 24 (03) :177-183
[7]   Preemptive Genotyping for Personalized Medicine: Design of the Right Drug, Right Dose, Right Time-Using Genomic Data to Individualize Treatment Protocol [J].
Bielinski, Suzette J. ;
Olson, Janet E. ;
Pathak, Jyotishman ;
Weinshilboum, Richard M. ;
Wang, Liewei ;
Lyke, Kelly J. ;
Ryu, Euijung ;
Targonski, Paul V. ;
Van Norstrand, Michael D. ;
Hathcock, Matthew A. ;
Takahashi, Paul Y. ;
McCormick, Jennifer B. ;
Johnson, Kiley J. ;
Maschke, Karen J. ;
Vitek, Carolyn R. Rohrer ;
Ellingson, Marissa S. ;
Wieben, Eric D. ;
Farrugia, Gianrico ;
Morrisette, Jody A. ;
Kruckeberg, Keri J. ;
Bruflat, Jamie K. ;
Peterson, Lisa M. ;
Blommel, Joseph H. ;
Skierka, Jennifer M. ;
Ferber, Matthew J. ;
Black, John L. ;
Baudhuin, Linnea M. ;
Klee, Eric W. ;
Ross, Jason L. ;
Veldhuizen, Tamra L. ;
Schultz, Cloann G. ;
Caraballo, Pedro J. ;
Freimuth, Robert R. ;
Chute, Christopher G. ;
Kullo, Iftikhar J. .
MAYO CLINIC PROCEEDINGS, 2014, 89 (01) :25-33
[8]  
Blackburn HL, 2015, CURR GENOMICS, V16, P159, DOI 10.2174/1389202916666150317232930
[9]   THE GENETIC-BASIS OF THE REDUCED EXPRESSION OF BILIRUBIN UDP-GLUCURONOSYLTRANSFERASE-1 IN GILBERTS-SYNDROME [J].
BOSMA, PJ ;
CHOWDHURY, JR ;
BAKKER, C ;
GANTLA, S ;
DEBOER, A ;
OOSTRA, BA ;
LINDHOUT, D ;
TYTGAT, GNJ ;
JANSEN, PLM ;
ELFERINK, RPJO ;
CHOWDHURY, NR .
NEW ENGLAND JOURNAL OF MEDICINE, 1995, 333 (18) :1171-1175
[10]   Added Value of Clinical Sequencing: WGS-Based Profiling of Pharmacogenes [J].
Caspar, Sylvan M. ;
Schneider, Timo ;
Meienberg, Janine ;
Matyas, Gabor .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (07)
12345678910