Cobalt-Catalyzed ortho-Alkylation of Secondary Benzamide with Alkyl Chloride through Directed C-H Bond Activation

被引：211

作者：

Chen, Quan ^{[1
]}

Ilies, Laurean ^{[1
]}

Nakamura, Eiichi ^{[1
]}

机构：

[1] Univ Tokyo, Sch Sci, Dept Chem, Bunkyo Ku, Tokyo 1130033, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2011年 / 133卷 / 03期

基金：

日本科学技术振兴机构;

关键词：

CROSS-COUPLING REACTIONS; DIRECT ARYLATION; CARBON-HYDROGEN; IRON; REAGENTS; BROMIDES; IMINES; SP(2);

D O I：

10.1021/ja1099853

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Coupling of an alkyl chloride with a secondary benzamide derivative at the ortho-position can be achieved in good to excellent yield in the presence of a cobalt catalyst and cyclohexylmagnesium chloride in diethyl ether at room temperature. Cyclohexylmagnesium chloride formally acts to remove hydrogen atoms from the amide nitrogen and from the ortho-position and to generate the active cobalt species.

引用

页码：428 / 429

页数：2

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