Multiple sclerosis: clinical profiling and data collection as prerequisite for personalized medicine approach

被引:66
作者
Ziemssen, Tjalf [1 ]
Kern, Raimar [1 ]
Thomas, Katja [1 ]
机构
[1] Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Dept Neurol, MS Ctr Dresden,Ctr Clin Neurosci, Fetscherstr 74, D-01307 Dresden, Germany
来源
BMC NEUROLOGY | 2016年 / 16卷
关键词
Multiple sclerosis; Personalized medicine; Multiple Sclerosis Documentation System; PATIENT-REPORTED OUTCOMES; LONG-TERM; MANAGEMENT-SYSTEM; DISEASE-ACTIVITY; UK MS; REGISTRY; CLASSIFICATION; DISABILITY; DESIGN; TRIALS;
D O I
10.1186/s12883-016-0639-7
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Multiple sclerosis (MS) is a highly heterogeneous disease as it can present inter-individually as well as intra-individually, with different disease phenotypes emerging during different stages in the long-term disease course. In addition to advanced immunological, genetic and magnetic resonance imaging (MRI) profiling of the patient, the clinical profiling of MS patients needs to be widely implemented in clinical practice and improved by including a greater range of relevant parameters as patient-reported outcomes. It is crucial to implement a high standard of clinical characterization of individual patients as this is key to effective long-term observation and evaluation. To generate reliable real-world data, individual clinical data should be collected in specific MS registries and/or using intelligent software instruments as the Multiple Sclerosis Documentation System 3D. Computational analysis of biological processes will play a key role in the transition to personalized MS treatment. Major breakthroughs in the areas of bioinformatics and computational systems biology will be required to process this complex information to enable improved personalization of treatment for MS patients.
引用
收藏
页数:10
相关论文
共 69 条
[1]  
[Anonymous], MULTIPLE SCLEROSIS I
[2]   Evaluating loss of visual function in multiple sclerosis as measured by low-contrast letter acuity [J].
Balcer, Laura J. ;
Frohman, Elliot M. .
NEUROLOGY, 2010, 74 (17) :S16-S23
[3]   MSBase:: an international, online registry and platform for collaborative outcomes research in multiple sclerosis [J].
Butzkueven, H. ;
Chapman, J. ;
Cristiano, E. ;
Grand'Maison, F. ;
Hoffmann, M. ;
Izquierdo, G. ;
Jolley, D. ;
Kappos, L. ;
Leist, T. ;
Poehlau, D. ;
Rivera, V. ;
Trojano, M. ;
Verheul, F. ;
Malkowski, J-P .
MULTIPLE SCLEROSIS, 2006, 12 (06) :769-774
[4]   International Pediatric MS Study Group Clinical Trials Summit Meeting report [J].
Chitnis, Tanuja ;
Tardieu, Marc ;
Amato, Maria Pia ;
Banwell, Brenda ;
Bar-Or, Amit ;
Ghezzi, Angelo ;
Kornberg, Andrew ;
Krupp, Lauren B. ;
Pohl, Daniela ;
Rostasy, Kevin ;
Tenembaum, Silvia ;
Waubant, Emmanuelle ;
Wassmer, Evangeline .
NEUROLOGY, 2013, 80 (12) :1161-1168
[5]   MS-CANE: a computer-aided instrument for neurological evaluation of patients with multiple sclerosis: enhanced reliability of expanded disability status scale (EDSS) assessment [J].
Cohen, YC ;
Hassin-Baer, S ;
Olmer, L ;
Barishev, R ;
Goldhammer, Y ;
Freedman, L ;
Mozes, B .
MULTIPLE SCLEROSIS, 2000, 6 (05) :355-361
[6]   Multiple sclerosis [J].
Compston, A ;
Coles, A .
LANCET, 2002, 359 (9313) :1221-1231
[7]  
Cook Stuart D, 2012, Int J MS Care, V14, P105, DOI 10.7224/1537-2073-14.3.105
[8]   Capturing Patient-Reported Outcome (PRO) Data Electronically: The Past, Present, and Promise of ePRO Measurement in Clinical Trials [J].
Coons, Stephen Joel ;
Eremenco, Sonya ;
Lundy, J. Jason ;
O'Donohoe, Paul ;
O'Gorman, Hannah ;
Malizia, William .
PATIENT-PATIENT CENTERED OUTCOMES RESEARCH, 2015, 8 (04) :301-309
[9]   Therapy optimization in multiple sclerosis: a prospective observational study of therapy compliance and outcomes [J].
Coyle, Patricia K. ;
Cohen, Bruce A. ;
Leist, Thomas ;
Markowitz, Clyde ;
Oleen-Burkey, MerriKay ;
Schwartz, Marc ;
Tullman, Mark J. ;
Zwibel, Howard .
BMC NEUROLOGY, 2014, 14
[10]   Active and progressive A new duality of MS classification [J].
Cross, Anne H. ;
Wingerchuk, Dean M. ;
Weinshenker, Brian G. .
NEUROLOGY, 2014, 83 (03) :206-207