Hyperpatulones C-G, new spirocyclic polycyclic polyprenylated acylphloroglucinols from the leaves of Hypericum patulum

被引：5
|
作者：
Zhang, Yu-xin [1 ]
Ao, Zhen [1 ]
He, Yi-wen [1 ]
Lu, Jin-Yu [1 ]
Chen, Xin-lin [1 ]
Kong, Ling-yi [1 ]
Luo, Jian-guang [1 ]
机构：
[1] China Pharmaceut Univ, Sch Tradit Chinese Pharm, State Key Lab Nat Med, Jiangsu Key Lab Bioact Nat Prod Res, 24 Tong Jia Xiang, Nanjing 210009, Peoples R China
来源：
FITOTERAPIA | 2021年 / 155卷
基金：
中国国家自然科学基金;
关键词：
Hypericum patulum; Spirocyclic polycyclic polyprenylated acylphloroglucinols; alpha-Glucosidase inhibitory activity; A-C; DERIVATIVES; FLOWERS;
D O I：
10.1016/j.fitote.2021.105063
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Five new spimcyclic polycyclic polyprenylated acylphloroglucinols, Hyperpatulones C-G (1-5), were obtained from the leaves of Hypericum patulum. Their structures were characterized by the comprehensive analysis of their IR, NMR, CD spectra and HRESIMS data. All the new compounds were evaluated for the alpha-glycosidase inhibitory activities. Among them, compounds 3-5 showed alpha-glucosidase inhibitory activities, with IC(50 )values of 14.06-37.69 mu M.
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收藏
页数：5
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