High efficiency activation of L-type Ca2+ current by 5-HT in human atrial myocytes

被引：4
作者：
Di Scala, E
Findlay, I
Rose, S
Aupart, M
Argibay, J
Cosnay, P
Bozon, V
机构：
[1] Univ Tours, CNRS, UMR 6542, Fac Sci, F-37200 Tours, France
[2] CHU Trousseau, Serv Chirurg Cardiaque, Tours, France
[3] CHU Trousseau, Serv Cardiol B, Tours, France
来源：
RECEPTORS & CHANNELS | 2004年 / 10卷 / 5-6期
关键词：
atrial fibrillation; Ca current; cAMP; human atrial myocytes; serotonin;
D O I：
10.1080/10606820490926115
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In human atrial myocytes, serotonin rather than sympathetic, stimulation is more frequently associated with atrial fibrillation. So does the arrhythmogenic effect of serotonin result from the mechanism of action of the receptor or the context of its action upon cardiac myocytes? The capacity of agonists to produce cAMP followed the sequence 5-HT < Iso < Forskolin to increase ICaL with 5-HT = Iso = Forskolin. The simultaneous application of threshold concentrations of 5-HT and Iso maximally increased ICaL. We will show that the effect of 5-HT upon human atrial myocytes is an imbalance between low production of cAMP and maximal activation of ICaL.
引用
收藏
页码：159 / 165
页数：7
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