Spirooxindoles as Potential Pharmacophores

被引：93
作者：
Panda, Siva S. [1 ]
Jones, Rachel A. [2 ]
Bachawala, Praveen [3 ]
Mohapatra, Prabhu P. [1 ]
机构：
[1] Augusta Univ, Dept Chem & Phys, Augusta, GA 30912 USA
[2] Univ Florida, Dept Chem, Ctr Heterocycl Cpds, Gainesville, FL 32611 USA
[3] MilliporeSigma Pvt Ltd, Isotec Div, Miamisburg, OH 45342 USA
来源：
MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2017年 / 17卷 / 16期
关键词：
Biological importance; chemistry; heterocycles; pharmacophores; spirooxindoles; synthesis; DIVERSITY-ORIENTED SYNTHESIS; REGIOSELECTIVE SYNTHESIS; BIOLOGICAL EVALUATION; SPIROINDOLONE KAE609; DESIGN; DERIVATIVES; DISCOVERY; OXINDOLE; CONSTRUCTION; QSAR;
D O I：
10.2174/1389557516666160624125108
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Objective: The spirooxindole heterocyclic scaffold is found in many natural products and has been identified as an important bioactive agent. Background: Over the past few decades, various spirooxindole-containing compounds have been reported to possess biological properties and hence found in the structure of many synthetic pharmaceuticals. This mini-review describes the most promising examples of this class of compounds possessing biological activity including anticancer, anti-inflammatory, and antimicrobial activities. Conclusion: The current review focuses on the biological activity of compounds containing the spirooxindole scaffold.
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页码：1515 / 1536
页数：22
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