2-Piperidin-4-yl-benzimidazoles with broad spectrum antibacterial activities

被引：82

作者：

He, Y ^{[1
]}

Wu, BG ^{[1
]}

Yang, J ^{[1
]}

Robinson, D ^{[1
]}

Risen, L ^{[1
]}

Ranken, R ^{[1
]}

Blyn, L ^{[1
]}

Sheng, S ^{[1
]}

Swayze, EE ^{[1
]}

机构：

[1] Isis Pharmaceut Inc, Div A, Ibis Therapeut, Carlsbad, CA 92008 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 19期

关键词：

D O I：

10.1016/S0960-894X(03)00661-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 2-piperidin-4-yl-benzimidazoles were synthesized and evaluated for antibacterial activities. Certain compounds inhibit bacterial growth with low micromolar minimal inhibitory concentration (MIC). These benzimidazoles arc effective against both Gram-positive and Gram-negative bacteria of clinical importance, particularly entercococci, and represent a new class of potential antibacterial agents. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：3253 / 3256

页数：4

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