A biocompatible 3D printed microfluidic C. elegans analysis device

被引:3
作者
Burchard, Taylor [1 ,2 ]
Putzke, Aaron [2 ]
Measor, Philip [1 ]
机构
[1] Whitworth Univ, Engn & Phys Dept, 300 W Hawthorne Rd, Spokane, WA 99251 USA
[2] Whitworth Univ, Biol Dept, 300 W Hawthorne Rd, Spokane, WA 99251 USA
来源
MICROFLUIDICS, BIOMEMS, AND MEDICAL MICROSYSTEMS XX | 2022年 / 11955卷
关键词
3D printing; microfluidic; biocompatible; C; elegans; PEGDA; hydrogel; stereolithography; chip;
D O I
10.1117/12.2608391
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
A 3D printed microfluidic device for Caenorhabditis elegans analysis. The biocompatibility of the 3D printed poly(ethylene glycol) diacrylate hydrogel resin was conducted and had no observable effect on worm lifespans. Worm organ morphology was directly observable through the microfluidic device and low autofluorescence was demonstrated using genetically-modified pharynx fluorescent worms.
引用
收藏
页数:4
相关论文
共 9 条
[1]   Medical significance of Caenorhabditis elegans [J].
Aboobaker, AA ;
Blaxter, ML .
ANNALS OF MEDICINE, 2000, 32 (01) :23-30
[2]  
[Anonymous], 2019, bioRxiv
[3]   Custom 3D printer and resin for 18 μm x 20 μm microfluidic flow channels [J].
Gong, Hua ;
Bickham, Bryce P. ;
Woolley, Adam T. ;
Nordin, Gregory P. .
LAB ON A CHIP, 2017, 17 (17) :2899-2909
[4]   Cancer Models in Caenorhabditis elegans [J].
Kirienko, Natalia V. ;
Mani, Kumaran ;
Fay, David S. .
DEVELOPMENTAL DYNAMICS, 2010, 239 (05) :1413-1448
[5]  
Nigon Victor Marc, 2017, WormBook, V2017, P1, DOI 10.1895/wormbook.1.181.1
[6]  
Shrestha S., 2019, MURDOCK COLL SCI RES
[7]   Biocompatible PEGDA Resin for 3D Printing [J].
Warr, Chandler ;
Valdoz, Jonard Corpuz ;
Bickham, Bryce P. ;
Knight, Connor J. ;
Franks, Nicholas A. ;
Chartrand, Nicholas ;
Van Ry, Pam M. ;
Christensen, Kenneth A. ;
Nordin, Gregory P. ;
Cook, Alonzo D. .
ACS APPLIED BIO MATERIALS, 2020, 3 (04) :2239-2244
[8]   The origins and the future of microfluidics [J].
Whitesides, George M. .
NATURE, 2006, 442 (7101) :368-373
[9]   Two conserved epigenetic regulators prevent healthy ageing [J].
Yuan, Jie ;
Chang, Si-Yuan ;
Yin, Shi-Gang ;
Liu, Zhi-Yang ;
Cheng, Xiu ;
Liu, Xi-Juan ;
Jiang, Qiang ;
Gao, Ge ;
Lin, De-Ying ;
Kang, Xin-Lei ;
Ye, Shi-Wei ;
Chen, Zheng ;
Yin, Jiang-An ;
Hao, Pei ;
Jiang, Lubin ;
Cai, Shi-Qing .
NATURE, 2020, 579 (7797) :118-+