Involvement of miRNA polymorphism in mucositis development in childhood acute lymphoblastic leukemia treatment

被引：11

作者：

Gutierrez-Camino, Angela ^{[1
,2
]}

Umerez, Maitane ^{[1
]}

Lopez-Lopez, Elixabet ^{[1
,2
]}

Santos-Zorrozua, Borja ^{[1
]}

Martin-Guerrero, Idoia ^{[1
,2
]}

Garcia de Andoin, Nagore ^{[3
,4
]}

Ana, Sastre ^{[5
]}

Navajas, Aurora ^{[2
,6
]}

Astigarraga, Itziar ^{[2
,4
,6
]}

Garcia-Orad, Africa ^{[1
,2
]}

机构：

[1] Univ Basque Country, Dept Genet Phys Anthropol & Anim Physiol, UPV EHU, Leioa 48940, Spain

[2] BioCruces Hlth Res Inst, Baracaldo 48903, Spain

[3] Univ Hosp Donostia, Dept Pediat, San Sebastian 20014, Spain

[4] Univ Basque Country, Dept Pediat, UPV EHU, Leioa 48940, Spain

[5] Univ Hosp La Paz, Dept Oncohematol, Madrid 28046, Spain

[6] Univ Hosp Cruces, Dept Pediat, Baracaldo 48903, Spain

来源：

PHARMACOGENOMICS | 2018年 / 19卷 / 18期

关键词：

acute lymphoblastic leukemia; chemotherapy; miRNA; mucositis; SNP; PRIMARY MICRORNAS; ORAL MUCOSITIS; GENES; EXPRESSION; IDENTIFICATION; PERSPECTIVES; BIOMARKERS; PHENOTYPE; TOXICITY; DATABASE;

D O I：

10.2217/pgs-2018-0113

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Aim: Mucositis, linked to methotrexate, daunorubicin or cyclophosphamide, is a frequent childhood acute lymphoblastic leukemia (ALL) therapy side effect. miRNAs regulate the expression of pharmacokinetic/pharmacodynamic pathway genes. SNPs in miRNAs could affect their levels or function, and affect their pharmacokinetic/pharmacodynamic pathway target genes. Our aim was to determine the association between miRNA genetic variants targeting mucositis-related genes and mucositis-developing risk. Patients & methods: We analyzed 160 SNPs in 179 Spanish children with B-cell precursor ALL homogeneously treated with LAL/SHOP protocols. Results: We identified three SNPs in miR-4268, miR-4751 and miR-3117 associated with mucositis, diarrhea and vomiting, respectively. Conclusion: The effect of these SNPs on genes related to drug pharmacokinetics/pharmacodynamics could explain mucositis, diarrhea and vomiting development during ALL therapy.

引用

页码：1403 / 1412

页数：10

共 49 条

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