Agosterol A, a novel polyhydroxylated sterol acetate reversing multidrug resistance from a marine sponge of Spongia sp.

被引：61

作者：

Aoki, S

Yoshioka, Y

Miyamoto, Y

Higuchi, K

Setiawan, A

Murakami, N

Chen, ZS

Sumizawa, T

Akiyama, S

Kobayashi, M

机构：

[1] Osaka Univ, Fac Pharmaceut Sci, Suita, Osaka 565, Japan

[2] Kagoshima Univ, Fac Med, Inst Canc Res, Kagoshima 890, Japan

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 35期

关键词：

steroids and sterols; sponges; antitumour compounds; stereochemistry;

D O I：

10.1016/S0040-4039(98)01336-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Agosterol A (1) has been isolated from a marine sponge of Spongia sp. and the absolute stereostructure elucidated. Agosterol A (1) is a novel polyhydroxylated sterol acetate, which completely reverses multidrug resistance in human carcinoma cells caused by overexpression of two kinds of membrane glycoprotein. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：6303 / 6306

页数：4

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