Agosterol A, a novel polyhydroxylated sterol acetate reversing multidrug resistance from a marine sponge of Spongia sp.

被引：60
作者：
Aoki, S
Yoshioka, Y
Miyamoto, Y
Higuchi, K
Setiawan, A
Murakami, N
Chen, ZS
Sumizawa, T
Akiyama, S
Kobayashi, M
机构：
[1] Osaka Univ, Fac Pharmaceut Sci, Suita, Osaka 565, Japan
[2] Kagoshima Univ, Fac Med, Inst Canc Res, Kagoshima 890, Japan
来源：
TETRAHEDRON LETTERS | 1998年 / 39卷 / 35期
关键词：
steroids and sterols; sponges; antitumour compounds; stereochemistry;
D O I：
10.1016/S0040-4039(98)01336-7
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Agosterol A (1) has been isolated from a marine sponge of Spongia sp. and the absolute stereostructure elucidated. Agosterol A (1) is a novel polyhydroxylated sterol acetate, which completely reverses multidrug resistance in human carcinoma cells caused by overexpression of two kinds of membrane glycoprotein. (C) 1998 Elsevier Science Ltd. All rights reserved.
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收藏
页码：6303 / 6306
页数：4
相关论文
共 9 条
  • [1] ISOLATION AND GENETIC-CHARACTERIZATION OF HUMAN KB-CELL LINES RESISTANT TO MULTIPLE-DRUGS
    AKIYAMA, SI
    FOJO, A
    HANOVER, JA
    PASTAN, I
    GOTTESMAN, MM
    [J]. SOMATIC CELL AND MOLECULAR GENETICS, 1985, 11 (02) : 117 - 126
  • [2] OVEREXPRESSION OF A TRANSPORTER GENE IN A MULTIDRUG-RESISTANT HUMAN LUNG-CANCER CELL-LINE
    COLE, SPC
    BHARDWAJ, G
    GERLACH, JH
    MACKIE, JE
    GRANT, CE
    ALMQUIST, KC
    STEWART, AJ
    KURZ, EU
    DUNCAN, AMV
    DEELEY, RG
    [J]. SCIENCE, 1992, 258 (5088) : 1650 - 1654
  • [3] THE LEUKOTRIENE LTD(4) RECEPTOR ANTAGONIST MK571 SPECIFICALLY MODULATES MRP ASSOCIATED MULTIDRUG-RESISTANCE
    GEKELER, V
    ISE, W
    SANDERS, KH
    ULRICH, WR
    BECK, J
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1995, 208 (01) : 345 - 352
  • [4] HOMOLOGY BETWEEN P-GLYCOPROTEIN AND A BACTERIAL HEMOLYSIN TRANSPORT PROTEIN SUGGESTS A MODEL FOR MULTIDRUG RESISTANCE
    GERLACH, JH
    ENDICOTT, JA
    JURANKA, PF
    HENDERSON, G
    SARANGI, F
    DEUCHARS, KL
    LING, V
    [J]. NATURE, 1986, 324 (6096) : 485 - 489
  • [5] Isomerization of dimeric 2,9-disubstituted 1-oxa-quinolizidine alkaloids and structural revision of araguspongines B and E, isolated from a marine sponge of Xestospongia sp.
    Kobayashi, M
    Miyamoto, Y
    Aoki, S
    Murakami, N
    Kitagawa, I
    In, Y
    Ishida, T
    [J]. HETEROCYCLES, 1998, 47 (01) : 195 - 203
  • [6] ABSOLUTE-CONFIGURATIONS OF CYTO-TOXIC MARINE CEMBRANOLIDES - CONSIDERATION OF MOSHERS METHOD
    KUSUMI, T
    OHTANI, I
    INOUYE, Y
    KAKISAWA, H
    [J]. TETRAHEDRON LETTERS, 1988, 29 (37) : 4731 - 4734
  • [7] Absolute stereostructure of callystatin A, a potent cytotoxic polyketide from the marine sponge, Callyspongia truncata
    Murakami, N
    Wang, WQ
    Aoki, M
    Tsutsui, Y
    Higuchi, K
    Aoki, S
    Kobayashi, M
    [J]. TETRAHEDRON LETTERS, 1997, 38 (31) : 5533 - 5536
  • [8] NAGAYAMA S, IN PRESS CANC LETT
  • [9] Sumizawa T, 1997, MOL PHARMACOL, V51, P399
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