Meta-Analysis of Usefulness of Psyllium Fiber as Adjuvant Antilipid Therapy to Enhance Cholesterol Lowering Efficacy of Statins

被引:33
作者
Brum, Jose [1 ]
Ramsey, David [1 ]
McRorie, Johnson [1 ]
Bauer, Brent [2 ]
Kopecky, Stephen Louis [2 ]
机构
[1] Procter & Gamble Hlth Care, 8700 Mason Montgomery Rd, Mason, OH 45040 USA
[2] Mayo Clin Fdn, Rochester, MN 55902 USA
关键词
SERUM-CHOLESTEROL; HYPERCHOLESTEROLEMIC SUBJECTS; LIPOPROTEIN METABOLISM; SOLUBLE FIBER; HIGH-FAT; STEROLS; COMBINATION; DIETS; MEN;
D O I
10.1016/j.amjcard.2018.06.040
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Statins are usually well-tolerated drugs with a clear dose-dependent efficacy. However, manifestation of statin's side effects also bears a direct relation to higher doses necessary to achieve high impact cholesterol-lowering effects. Nevertheless, the reliance on statin efficacy alone has often left dietary intervention underutilized even though studies have shown a reduction in serum cholesterol levels when dietary fiber intake is increased. In this meta-analysis, we investigated whether the concomitant use of psyllium, a gel-forming viscous soluble fiber, would cause further overall cholesterol lowering in subjects already receiving statins. A systematic review of the medical literature was performed and identified three randomized, controlled clinical studies that evaluated the cholesterol lowering efficacy of statins when given concomitantly with psyllium as a fiber supplement. The duration of the studies ranged from 4 weeks to 12 weeks. The objective of the meta-analysis was to estimate the overall effect of psyllium plus statin versus statin alone. The results of the meta-analysis showed a clinically and statistically significant (p = 0.001) cholesterol lowering advantage for psyllium plus statin combination treatment over a statin alone. Adding psyllium fiber resulted in reductions in low-density lipoprotein-cholesterol equivalent to doubling the statin dose. In conclusion, the data support that psyllium fiber taken before meals adds to the efficacy of statins, providing an easy to implement dietary intervention for those who cannot tolerate side effects associated with higher-dose statins. (C) 2018 Elsevier Inc. All rights reserved.
引用
收藏
页码:1169 / 1174
页数:6
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