Increased Frontoparietal integration after Stroke and Cognitive Recovery

被引：57

作者：

Sharp, David J. ^{[1
,2
]}

Turkheimer, Federico E. ^{[1
,2
]}

Bose, Subrata K. ^{[1
]}

Scott, Sophie K. ^{[3
]}

Wise, Richard J. S. ^{[1
,2
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp Campus, Ctr Clin Sci, MRC, London W12 0NN, England

[2] Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp Campus, Div Neurosci & Mental Hlth, London W12 0NN, England

[3] UCL, Inst Cognit Neurosci, London, England

来源：

ANNALS OF NEUROLOGY | 2010年 / 68卷 / 05期

基金：

英国医学研究理事会; 英国工程与自然科学研究理事会; 英国惠康基金;

关键词：

FUNCTIONAL CONNECTIVITY; PARIETAL; REGIONS; SPEECH; RECOGNITION; NETWORKS;

D O I：

10.1002/ana.21866

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The neural mechanism by which patients spontaneously recover cognitive function after brain injury is not understood. Here we demonstrate for the first time that aphasic patients, who have largely recovered language function, show increased frontoparietal integration. A similar change in functional connectivity is also observed when normal subjects are exposed to adverse listening conditions. Thus, compensation for inefficient language processing is associated with increased integration between parts of the language network critical to language control. This change reflects greater top-down control of speech comprehension and provides a mechanism by which language impairments after stroke may be compensated for. ANN NEUROL 2010;68:753-756

引用

页码：753 / 756

页数：4

共 20 条

[1] Perisylvian language networks of the human brain
Catani, M
Jones, DK
Ffytche, DH
[J]. ANNALS OF NEUROLOGY, 2005, 57 (01) : 8 - 16
[2] DISCONNEXION SYNDROMES IN ANIMALS AND MAN
GESCHWIN.N
[J]. BRAIN, 1965, 88 : 237 - +
[3] Speed of lexical decision correlates with diffusion anisotropy in left parietal and frontal white matter: Evidence from diffusion tensor imaging
Gold, Brian T.
Powell, David K.
Xuan, Liang
Jiang, Yang
Hardy, Peter A.
[J]. NEUROPSYCHOLOGIA, 2007, 45 (11) : 2439 - 2446
[4] Common prefrontal regions coactivate with dissociable posterior regions during controlled semantic and phonological tasks
Gold, BT
Buckner, RL
[J]. NEURON, 2002, 35 (04) : 803 - 812
[5] Breakdown of functional connectivity in frontoparietal networks underlies behavioral deficits in spatial neglect
He, Biyu J.
Snyder, Abraham Z.
Vincent, Justin L.
Epstein, Adrian
Shulman, Gordon L.
Corbetta, Maurizio
[J]. NEURON, 2007, 53 (06) : 905 - 918
[6] Prolonged reaction time to a verbal working memory task predicts increased power of posterior parietal cortical activation
Honey, GD
Bullmore, ET
Sharma, T
[J]. NEUROIMAGE, 2000, 12 (05) : 495 - 503
[7] Functional connectivity of the angular gyrus in normal reading and dyslexia
Horwitz, B
Rumsey, JM
Donohue, BC
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (15) : 8939 - 8944
[8] Semantic impairment in stroke aphasia versus semantic dementia: a case-series comparison
Jefferies, Elizabeth
Ralph, Matthew A. Lambon
[J]. BRAIN, 2006, 129 : 2132 - 2147
[9] Large-Scale Neural Model Validation of Partial Correlation Analysis for Effective Connectivity Investigation in Functional MRI
Marrelec, G.
Kim, J.
Doyon, J.
Horwitz, B.
[J]. HUMAN BRAIN MAPPING, 2009, 30 (03) : 941 - 950
[10] From sensation to cognition
Mesulam, MM
[J]. BRAIN, 1998, 121 : 1013 - 1052

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