Altered level of salivary placental growth factor is associated with preeclampsia

被引：6
作者：
Rao, Shannon L. [1 ]
Taymoori, Ada [2 ]
Wong, David T. W. [1 ]
Maron, Jill L. [2 ]
机构：
[1] Univ Calif Los Angeles, Sch Dent, Los Angeles, CA 90024 USA
[2] Tufts Med Ctr, Mother Infant Res Inst, Boston, MA 02111 USA
来源：
PLACENTA | 2020年 / 90卷
关键词：
Preeclampsia; Salivary biomarker; Angiogenic factor; TYROSINE KINASE 1; ANGIOGENIC FACTORS; EARLY-ONSET; PREDICTION; BIOMARKERS; PREGNANCY; ACCURACY; RISK;
D O I：
10.1016/j.placenta.2019.12.016
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
A pilot, case-control study was conducted to compare the concentrations of placental growth factor (PlGF) and placental alkaline phosphatase (PLAP) in saliva of preeclampsia (PE) patients with normotensive controls in the second and third trimesters. Measured by ELISA assays, levels of salivary PlGF were significantly lower in PE patients (n = 13) compared to controls (n = 15) (two-way ANOVA, p = 0.0208) independent of gestational age at time of collection (p = 0.49). Salivary PLAP differences between PE and controls were not statistically significant. Placenta-specific proteins are detectable in maternal saliva and may serve as noninvasive biomarkers to monitor placenta health and disease during pregnancy.
引用
收藏
页码：118 / 120
页数：3
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