Dendritic cell maturation induced by high-mobility-group box protein 1 (HMGB1)

被引：0

作者：

Messmer, D ^{[1
]}

Yang, H ^{[1
]}

Telusma, G ^{[1
]}

Knoll, F ^{[1
]}

Li, J ^{[1
]}

Messmer, B ^{[1
]}

Tracey, KJ ^{[1
]}

Chiorazzi, N ^{[1
]}

机构：

[1] N Shore LIJ Res Inst, Expt Immunol Lab, Manhasset, NY 11030 USA

来源：

IMMUNOLOGY 2004: GENOMIC ISSUES, IMMUNE SYSTEM ACTIVATION AND ALLERGY | 2004年

关键词：

D O I：

暂无

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We show that HMGB 1, via its B box domain, induced phenotypic maturation of dendritic cells (DCs) as evidenced by increased adhesion and costimulatory molecules. The B box caused increased secretion of the proinflammatory cytokines and chemokines. Furthermore, B box-activated DCs acted as potent stimulators of allogeneic T cells. B box also induced secretion of IL-12 from DCs as well as IL-2 and IFN-gamma secretion from allogeneic T cells suggesting a Th1 bias.

引用

页码：259 / 264

页数：6

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