Development of Secondary T-Cell Acute Lymphoblastic Leukemia in a Child With Hemophagocytic Lymphohistiocytosis

被引：6

作者：

Shamsian, Bibi Shahin ^{[1
]}

Gharib, Atoosa ^{[2
]}

Rezaei, Nima ^{[3
]}

Esfahani, Shadi Abdar ^{[3
]}

Alavi, Samin ^{[1
]}

Goudarzipour, Kourosh ^{[1
]}

Arzanian, Mohammad Taghi ^{[1
]}

机构：

[1] Shahid Beheshti Med Univ, Dept Pediat Hematol Oncol, Mofid Children Hosp, Tehran, Iran

[2] Shahid Beheshti Med Univ, Dept Pathol, Mofid Children Hosp, Tehran, Iran

[3] Univ Tehran Med Sci, Rech Grp Immunodeficiencies, Childrens Med Ctr, Tehran, Iran

来源：

PEDIATRIC BLOOD & CANCER | 2010年 / 55卷 / 04期

关键词：

acute lymphoblastic leukemia; hemophagocytic lymphohistiocytosis; neoplasm; ACUTE MYELOID-LEUKEMIA; THERAPY; ONSET;

D O I：

10.1002/pbc.22578

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hemophagocytic lymphohistiocytosis (HLH) is a severe life-threatening disorder, characterized by hyperactivation of macrophages A 12-year-old female was referred to our center, the diagnosis of HLH was made for the patient and immunosuppressive regimen was started After a 2-year follow-up, the patient developed secondary T-cell acute lymphoblastic leukemia (T-ALL), confirmed by flow cytometric studies Treatment was started based on T-ALL protocol, but the patient died because of relapse and sepsis This case highlights the issue of secondary malignancy following HLH and demonstrates the need for continued follow-up in such patients Pediatr Blood Cancer 2010,55 725-726 (C) 2010 Wiley-Liss, Inc

引用

页码：725 / 726

页数：2

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