Alzheimer's disease, a multifactorial disorder seeking multitherapies

被引：194

作者：

Iqbal, Khalid ^{[1
]}

Grundke-Iqbal, Inge ^{[1
]}

机构：

[1] New York State Inst Basic Res Dev Disabil, Staten Isl, NY 10314 USA

来源：

ALZHEIMERS & DEMENTIA | 2010年 / 6卷 / 05期

关键词：

Alzheimer disease subgroups; Cerebrospinal fluid; CSF biomarkers; A beta(1-42); Tau; Ubiquitin; Alzheimer disease therapeutics; Neurofibrillary degeneration; beta-amyloid; PAIRED HELICAL FILAMENTS; NEUROFIBRILLARY TANGLES; TAU-PROTEIN; ABNORMAL PHOSPHORYLATION; HYPERPHOSPHORYLATED TAU; DEMENTIA; MICROTUBULES; PHOSPHATASES; UBIQUITIN; COMPONENT;

D O I：

10.1016/j.jalz.2010.04.006

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Alzheimer's disease (AD) is multifactorial and apparently involves several different etiopathogenic mechanisms. There are at least five subgroups of AD based on cerebrospinal fluid levels of A beta(1-42), a marker of beta-amyloid (A beta) plaques, and tau and ubiquitin, two markers of neurofibrillary tangles. These different AD subgroups may respond differently to a given disease-modifying drug, and hence, different therapeutic drugs for different disease subgroups might be required. Stratification of AD patients by disease subgroups in clinical trials is critical to the successful development of potent disease-modifying drugs. Levels of disease markers in the cerebrospinal fluid are promising, both in identifying various subgroups of AD and in monitoring the response to therapeutic drugs. (c) 2010 The Alzheimer's Association. All rights reserved.

引用

页码：420 / 424

页数：5

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