Verification that common variation at 2q37.1, 6p25.3, 11q24.1, 15q23, and 19q13.32 influences chronic lymphocytic leukaemia risk

被引：31

作者：

Crowther-Swanepoel, Dalemari ^{[1
]}

Mansouri, Mahmoud ^{[2
]}

Enjuanes, Anna ^{[3
]}

Vega, Ana ^{[4
,5
]}

Smedby, Karin E. ^{[6
]}

Ruiz-Ponte, Clara ^{[4
,5
]}

Jurlander, Jesper ^{[7
]}

Juliusson, Gunnar ^{[8
]}

Montserrat, Emilio ^{[9
]}

Catovsky, Daniel ^{[10
]}

Campo, Elias ^{[3
]}

Carracedo, Angel ^{[4
,5
]}

Rosenquist, Richard ^{[2
]}

Houlston, Richard S. ^{[1
]}

机构：

[1] Inst Canc Res, Sect Canc Genet, Sutton SM2 5NG, Surrey, England

[2] Uppsala Univ, Dept Genet & Pathol, Uppsala, Sweden

[3] Univ Barcelona, Hosp Clin, Dept Anat Pathol, Haematopathol Unit, E-08007 Barcelona, Spain

[4] Univ Santiago de Compostela, Genom Med Grp, Santiago De Compostela, Spain

[5] CIBERER, Galician Fdn Genom Med, Santiago De Compostela, Spain

[6] Karolinska Inst, Dept Med, Clin Epidemiol Unit, Stockholm, Sweden

[7] Rigshosp, Leukaemia Lab, Dept Haematol, DK-2100 Copenhagen, Denmark

[8] Lund Univ, Lund Strateg Res Ctr Stem Cell Biol & Cell Therap, Lund, Sweden

[9] Univ Barcelona, Hosp Clin, Inst Invest Biomed August Pi & Sunyer, Dept Haematol, E-08007 Barcelona, Spain

[10] Inst Canc Res, Sect Haematooncol, Sutton SM2 5NG, Surrey, England

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2010年 / 150卷 / 04期

关键词：

chronic lymphocytic leukaemia; risk; genotype; genome wide association; ZAP-70; EXPRESSION; CELL-RECEPTOR; IMMUNOGLOBULIN; LYMPHOMAS;

D O I：

10.1111/j.1365-2141.2010.08270.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

P>A recent genome wide association study of chronic lymphocytic leukaemia (CLL) provided evidence that common variation at 2q13 (rs17483466), 2q37.1 (rs13397985), 6p25.3 (rs872071), 11q24.1 (rs735665), 15q23 (rs7176508) and 19q13.32 (rs11083846) affects CLL risk. To verify and further explore the relationship between these variants and CLL risk we genotyped case-control datasets from Spain and Sweden (824 cases, 850 controls). Combined data provided statistically significant support for an association between genotypes at rs13397985, rs872071, rs735665, rs7176508 and rs11083846 and CLL risk. CLL risk increased with increasing numbers of risk alleles (P(trend) = 1 center dot 40 x 10-15), consistent with a polygenic model of disease susceptibility. These data validate the relationship between common variation and risk of CLL.

引用

页码：473 / 479

页数：7

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