A randomised controlled trial of memory flexibility training (MemFlex) to enhance memory flexibility and reduce depressive symptomatology in individuals with major depressive disorder

被引：27

作者：

Hitchcock, Caitlin ^{[1
,2
]}

Gormley, Siobhan ^{[1
]}

Rees, Catrin ^{[1
]}

Rodrigues, Evangeline ^{[1
]}

Gillard, Julia ^{[1
]}

Panesar, Inderpal ^{[1
,2
]}

Wright, Isobel M. ^{[1
,2
]}

Hammond, Emily ^{[1
]}

Watson, Peter ^{[1
]}

Werner-Seidler, Aliza ^{[3
]}

Dalgleish, Tim ^{[1
,2
]}

机构：

[1] Univ Cambridge, Med Res Council Cognit & Brain Sci Unit, Cambridge, England

[2] Cambridgeshire & Peterborough NHS Fdn Trust, Cambridge, England

[3] Black Dog Inst, Sydney, NSW, Australia

来源：

BEHAVIOUR RESEARCH AND THERAPY | 2018年 / 110卷

基金：

英国医学研究理事会;

关键词：

Depression; Low-intensity treatment; Autobiographical memory; Memory flexibility; Randomised controlled trial; COGNITIVE BIAS MODIFICATION; AUTOBIOGRAPHICAL MEMORY; NEGATIVE THINKING; MENTAL-HEALTH; SPECIFICITY; METAANALYSIS; IMAGERY; MOOD; ACCESSIBILITY; VULNERABILITY;

D O I：

10.1016/j.brat.2018.08.008

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

Successful navigation within the autobiographical memory store is integral to daily cognition. Impairment in the flexibility of memory retrieval can thereby have a detrimental impact on mental health. This randomised controlled phase II exploratory trial (N = 60) evaluated the potential of a novel intervention drawn from basic science an autobiographical Memory Flexibility (MemFlex) training programme - which sought to ameliorate memory difficulties and improve symptoms of Major Depressive Disorder. MemFlex was compared to Psychoeducation (an evidence-based low-intensity intervention) to determine the likely range of effects on a primary cognitive target of memory flexibility at post-intervention, and co-primary clinical targets of self-reported depressive symptoms and diagnostic status at three-month follow-up. These effect sizes could subsequently be used to estimate sample size for a fully-powered trial. Results demonstrated small-moderate, though as expected statistically non-significant, effect sizes in favour of MemFlex for memory flexibility (d = 0.34, p =. 20), and loss of diagnosis (OR = 0.65, p = .48), along with the secondary outcome of depression-free days (d = 0.36, p = .18). A smaller effect size was - observed for between-group difference in self-reported depressive symptoms (d = 0.24, p = .35). Effect sizes in favour of MemFlex in this early-stage trial suggest that fully-powered evaluation of MemFlex may be warranted as an avenue to improving low-intensity treatment of depression. Trial registration: ClinicalTrials.gov, Identifier NCT02371291.

引用

页码：22 / 30

页数：9

共 57 条

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