Endogenous Progestogens and Colorectal Cancer Risk among Postmenopausal Women

被引:4
|
作者
Michels, Kara A. [1 ]
Geczik, Ashley M. [1 ]
Bauer, Doug C. [2 ,3 ]
Brinton, Louise A. [1 ]
Buist, Diana S. M. [4 ]
Cauley, Jane A. [5 ]
Dallal, Cher M. [6 ]
Falk, Roni T. [1 ]
Hue, Trisha F. [2 ]
Lacey, James V., Jr. [7 ]
LaCroix, Andrea Z. [8 ]
Tice, Jeffrey A. [3 ]
Xu, Xia [9 ]
Trabert, Britton [1 ]
机构
[1] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA
[2] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA
[3] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA
[4] Kaiser Permanente Washington Hlth Res Inst, Seattle, WA USA
[5] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA USA
[6] Univ Maryland, Sch Publ Hlth, College Pk, MD 20742 USA
[7] City Hope Natl Med Ctr, Dept Computat & Quantitat Med, Div Hlth Analyt, Duarte, CA USA
[8] Univ Calif San Diego, Dept Family & Prevent Med, Div Epidemiol, San Diego, CA 92103 USA
[9] Leidos Biomed Res Inc, Frederick, MD USA
基金
美国国家卫生研究院;
关键词
ORAL-CONTRACEPTIVE USE; ESTROGEN PLUS PROGESTIN; SEX-HORMONES; BREAST; METABOLITES; HEALTH; STATISTICS;
D O I
10.1158/1055-9965.EPI-20-1568
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: The role of progestogens in colorectal cancer development is poorly characterized. To address this, our group developed a highly sensitive assay to measure concentrations of seven markers of endogenous progestogen metabolism among postmenopausal women. Methods: The markers weremeasured in baseline serumcollected from postmenopausal women in a case-cohort study within the breast and bone follow-up to the fracture intervention trial (B similar to FIT). We followed women not using exogenous hormones at baseline (1992-1993) for up to 12 years: 187 women with incident colorectal cancer diagnosed during follow-up and a subcohort of 495 women selected on strata of age and clinical center. We used adjusted Cox regression models with robust variance to estimate risk for colorectal cancer [hazard ratios (HR), 95% confidence intervals (CI)]. Results: High concentrations of pregnenolone and progesterone were not associated with colorectal cancer [quintile(Q)5 versus Q1: pregnenolone HR, 0.71, 95% CI, 0.40-1.25; progesterone HR, 1.25; 95% CI, 0.71-2.22]. A trend of increasing risk was suggested, but statistically imprecise across quintiles of 17-hydroxypregnenolone (Q2 to Q5 HRs, 0.75-1.44; P-trend, 0.06). Conclusions: We used sensitive and reliable assays to measure multiple circulating markers of progestogen metabolism. Progestogens were generally unassociated with colorectal cancer risk in postmenopausal women. Impact: Our findings are consistent with most prior research on circulating endogenous sex hormones, which taken together suggest that sex hormones may not be major drivers of colorectal carcinogenesis in postmenopausal women.
引用
收藏
页码:1100 / 1105
页数:6
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