Effective combination therapy for invasive pneumococcal pneumonia with ampicillin and intravenous immunoglobulins in a mouse model

被引：19

作者：

De Hennezel, L

Ramisse, F

Binder, P

Marchal, G

Alonso, JM

机构：

[1] Ctr Etud Bouchet, F-91710 Vert Le Petit, France

[2] Serv Sante Armees, Direct Cent, F-00459 Armees, France

[3] Inst Pasteur, F-75015 Paris, France

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2001年 / 45卷 / 01期

关键词：

D O I：

10.1128/AAC.45.1.316-318.2001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Intranasal immunotherapy for Streptococcus pneumoniae invasive pneumonia with polyvalent immunoglobulins (IVIG) was effective in mice against pneumonia but failed to prevent bacteremia. The combination of subcurative doses of IVIG and of ampicillin was fully protective. Such an approach, successfully applied in the preantibiotic era, offers new perspectives for modern therapies.

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页码：316 / 318

页数：3

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