Dendritic Cells, Indoleamine 2,3 Dioxygenase and Acquired Immune Privilege

被引：83

作者：

Huang, Lei ^{[1
,2
]}

Baban, Babak ^{[1
,3
]}

Johnson, Burles A., III ^{[1
,4
]}

Mellor, Andrew L. ^{[1
,4
]}

机构：

[1] Med Coll Georgia, Immunotherapy Ctr, Augusta, GA 30912 USA

[2] Med Coll Georgia, Dept Radiol, Augusta, GA 30912 USA

[3] Med Coll Georgia, Dept Pathol, Augusta, GA 30912 USA

[4] Med Coll Georgia, Dept Med, Augusta, GA 30912 USA

来源：

INTERNATIONAL REVIEWS OF IMMUNOLOGY | 2010年 / 29卷 / 02期

关键词：

dendritic cells; indoleamine 2,3 dioxygenase; T cells; regulation; REGULATORY T-CELLS; DRAINING LYMPH-NODES; TRYPTOPHAN CATABOLISM; CUTTING EDGE; 2,3-DIOXYGENASE IDO; DEXTRO-1-METHYL TRYPTOPHAN; EXPERIMENTAL ASTHMA; ENDOTHELIAL-CELLS; INDUCED ARTHRITIS; INTERFERON-GAMMA;

D O I：

10.3109/08830180903349669

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Dendritic cells (DCs) are specialized to stimulate T cell immunity. Paradoxically, some DCs suppress T cell responses and activate regulatory T cells. In this review, we focus on a potent counter-regulatory pathway mediated by plasmacytoid DCs (pDCs) expressing the immunosuppressive enzyme indoleamine 2,3 dioxygenase (IDO). IDO-expressing pDCs inhibit effector T cell responses, activate regulatory T cells, and attenuate pro-inflammatory responses in settings of chronic inflammation that manifest in clinical syndromes, such as infectious, allergic, and autoimmune diseases; cancer; and transplantation. Thus, IDO-expressing pDCs create immune privilege and provide novel opportunities to improve immunotherapy in multiple disease syndromes.

引用

页码：133 / 155

页数：23

共 105 条

[31] Inhibition of experimental asthma by indoleamine 2,3-dioxygenase [J].

Hayashi, T ;

Beck, L ;

Rossetto, C ;

Gong, X ;

Takikawa, O ;

Takabayashi, K ;

Broide, DH ;

Carson, DA ;

Raz, E .

JOURNAL OF CLINICAL INVESTIGATION, 2004, 114 (02) :270-279

[32] 3-Hydroxyanthranilic acid inhibits PDK1 activation and suppresses experimental asthma by inducing T cell apoptosis [J].

Hayashi, Tolmoko ;

Mo, Ji-Hun ;

Gong, Xing ;

Rossetto, Cyprian ;

Jang, Angela ;

Beck, Lucinda ;

Elliott, Gregory I. ;

Kufareva, Irina ;

Abagyan, Ruben ;

Broide, David H. ;

Lee, Jongdae ;

Raz, Eyal .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (47) :18619-18624

[33] IDO expands human CD4+CD25high regulatory T cells by promoting maturation of LPS-treated dendritic cells [J].

Hill, Marcelo ;

Tanguy-Royer, Severine ;

Royer, Pierre ;

Chauveau, Christine ;

Asghar, Kashif ;

Tesson, Laurent ;

Lavainne, Frederic ;

Remy, Severine ;

Brion, Regis ;

Huber, Francois-Xavier ;

Heslan, Michele ;

Rimbert, Marie ;

Berthelot, Laureline ;

Moffett, John R. ;

Josien, Regis ;

Gregoire, Marc ;

Anegon, Ignacio .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2007, 37 (11) :3054-3062

[34] Inhibition of indoleamine 2,3-dioxygenase in dendritic cells by stereoisomers of 1-methyl-tryptophan correlates with antitumor responses [J].

Hou, De-Yan ;

Muller, Alexander J. ;

Sharma, Madhav D. ;

DuHadaway, James ;

Banerjee, Tinku ;

Johnson, Maribeth ;

Mellor, Andrew L. ;

Prendergasts, George C. ;

Munn, David H. .

CANCER RESEARCH, 2007, 67 (02) :792-801

[35] Indoleamine 2,3-dioxygenase production by human dendritic cells results in the inhibition of T cell proliferation [J].

Hwu, P ;

Du, MX ;

Lapointe, R ;

Do, M ;

Taylor, MW ;

Young, HA .

JOURNAL OF IMMUNOLOGY, 2000, 164 (07) :3596-3599

[36] Role of the immunosuppressive enzyme indoleamine 2,3-dioxygenase in the progression of ovarian carcinoma [J].

Inaba, Tomoko ;

Ino, Kazuhiko ;

Kajiyama, Hiroaki ;

Yamamoto, Eiko ;

Shibata, Kiyosumi ;

Nawa, Akihiro ;

Nagasaka, Tetsuro ;

Akimoto, Hidetoshi ;

Takikawa, Osamu ;

Kikkawa, Fumitaka .

GYNECOLOGIC ONCOLOGY, 2009, 115 (02) :185-192

[37] Small intestinal CD103+ dendritic cells display unique functional properties that are conserved between mice and humans [J].

Jaensson, Elin ;

Uronen-Hansson, Heli ;

Pabst, Oliver ;

Eksteen, Bertus ;

Tian, Jiong ;

Coombes, Janine L. ;

Berg, Pia-Lena ;

Davidsson, Thomas ;

Powrie, Fiona ;

Johansson-Lindbom, Bengt ;

Agace, William W. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2008, 205 (09) :2139-2149

[38] Toxicology and pharmacokinetics of 1-methyl-D-tryptophan: Absence of toxicity due to saturating absorption [J].

Jia, Lee ;

Schweikart, Karen ;

Tomaszewski, Joseph ;

Page, John G. ;

Noker, Patricia E. ;

Buhrow, Sarah A. ;

Reid, Joel M. ;

Ames, Matthew M. ;

Munn, David H. .

FOOD AND CHEMICAL TOXICOLOGY, 2008, 46 (01) :203-211

[39]

JOHNSON BA, IMMUNOTHERA IN PRESS

[40] Interferon-γ-triggered indoleamine 2,3-dioxygenase competence in human monocyte-derived dendritic cells induces regulatory activity in allogeneic T cells [J].

Juergens, Birgit ;

Hainz, Ursula ;

Fuchs, Dietmar ;

Felzmann, Thomas ;

Heitger, Andreas .

BLOOD, 2009, 114 (15) :3235-3243

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