Dendritic Cells, Indoleamine 2,3 Dioxygenase and Acquired Immune Privilege

被引：83

作者：

Huang, Lei ^{[1
,2
]}

Baban, Babak ^{[1
,3
]}

Johnson, Burles A., III ^{[1
,4
]}

Mellor, Andrew L. ^{[1
,4
]}

机构：

[1] Med Coll Georgia, Immunotherapy Ctr, Augusta, GA 30912 USA

[2] Med Coll Georgia, Dept Radiol, Augusta, GA 30912 USA

[3] Med Coll Georgia, Dept Pathol, Augusta, GA 30912 USA

[4] Med Coll Georgia, Dept Med, Augusta, GA 30912 USA

来源：

INTERNATIONAL REVIEWS OF IMMUNOLOGY | 2010年 / 29卷 / 02期

关键词：

dendritic cells; indoleamine 2,3 dioxygenase; T cells; regulation; REGULATORY T-CELLS; DRAINING LYMPH-NODES; TRYPTOPHAN CATABOLISM; CUTTING EDGE; 2,3-DIOXYGENASE IDO; DEXTRO-1-METHYL TRYPTOPHAN; EXPERIMENTAL ASTHMA; ENDOTHELIAL-CELLS; INDUCED ARTHRITIS; INTERFERON-GAMMA;

D O I：

10.3109/08830180903349669

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Dendritic cells (DCs) are specialized to stimulate T cell immunity. Paradoxically, some DCs suppress T cell responses and activate regulatory T cells. In this review, we focus on a potent counter-regulatory pathway mediated by plasmacytoid DCs (pDCs) expressing the immunosuppressive enzyme indoleamine 2,3 dioxygenase (IDO). IDO-expressing pDCs inhibit effector T cell responses, activate regulatory T cells, and attenuate pro-inflammatory responses in settings of chronic inflammation that manifest in clinical syndromes, such as infectious, allergic, and autoimmune diseases; cancer; and transplantation. Thus, IDO-expressing pDCs create immune privilege and provide novel opportunities to improve immunotherapy in multiple disease syndromes.

引用

页码：133 / 155

页数：23

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