Potent, low molecular weight thrombin receptor antagonists

被引：24

作者：

Chackalamannil, S ^{[1
]}

Doller, D ^{[1
]}

Eagen, K ^{[1
]}

Czarniecki, M ^{[1
]}

Ahn, HS ^{[1
]}

Foster, CJ ^{[1
]}

Boykow, G ^{[1
]}

机构：

[1] Schering Plough Corp, Res Inst, Kenilworth, NJ 07033 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 21期

关键词：

D O I：

10.1016/S0960-894X(01)00555-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Several benzimidazole derivatives have been identified as potent thrombin receptor (PAR-1) antagonists as represented by compound 1h, which showed an IC50 of 33 nM. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：2851 / 2853

页数：3

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