Dupilumab efficacy and safety in patients with moderate to severe asthma: A systematic review and meta-analysis

被引：9

作者：

Zaazouee, Mohamed Sayed ^{[1
]}

Alwarraqi, Asmaa Gomaa ^{[2
]}

Mohammed, Yasmine Adel ^{[3
]}

Badheeb, Mohamed A. ^{[4
]}

Farhat, Abdullah Mohamed ^{[5
]}

Eleyan, Mohammed ^{[6
,7
]}

Morad, Afnan ^{[3
]}

Zeid, Marwa Abdel-Aziz ^{[8
,9
]}

Mohamed, Aya Shaban ^{[10
]}

AbuEl-Enien, Hazem ^{[11
]}

Abdelalim, Ahmed ^{[12
]}

Elsnhory, Ahmed Bostamy ^{[13
]}

Hrizat, Yasmin S. M. ^{[14
]}

Altahir, Nagat Taha ^{[15
]}

Atef, Doaa ^{[16
]}

Elshanbary, Alaa Ahmed ^{[2
]}

Alsharif, Khalaf F. ^{[17
]}

Alzahrani, Khalid J. ^{[17
]}

Algahtani, Mohammad ^{[18
]}

Theyab, Abdulrahman ^{[18
,19
]}

Hawsawi, Yousef M. ^{[19
,20
]}

Aldarmahi, Ahmed A. ^{[21
]}

Abdel-Daim, Mohamed M. ^{[22
,23
]}

机构：

[1] Al Azhar Univ, Fac Med, Assiut, Egypt

[2] Alexandria Univ, Fac Med, Alexandria, Egypt

[3] Assiut Univ, Fac Med, Assiut, Egypt

[4] Hadhramout Univ, Coll Med, Al Mukalla, Yemen

[5] Fayoum Univ, Fac Med, Al Fayyum, Egypt

[6] Alaqsa Univ, Dept Lab Med Sci, Gaza, Palestine

[7] Al Azhar Univ, Fac Med, Gaza, Palestine

[8] Minist Hlth, Pediat Dept, Clin Pharm, Qalyubia, Egypt

[9] October 6 Univ, Fac Pharm, Giza, Egypt

[10] Assiut Univ, Fac Med, Dept Pharmacol, Assiut, Egypt

[11] Pharos Univ, Fac Pharm & Drug Mfg, Alexandria, Egypt

[12] Al Azhar Univ, Fac Pharm, Cairo, Egypt

[13] Al Azhar Univ, Fac Med, Cairo, Egypt

[14] Univ Jordan, Fac Med, Amman, Jordan

[15] Khartoum Univ, Fac Nursing, Khartoum, Sudan

[16] Assiut Univ, Dept Emergency Med, Assiut, Egypt

[17] Taif Univ, Coll Appl Med Sci, Dept Clin Lab Sci, Taif, Saudi Arabia

[18] Secur Forces Hosp, Dept Lab & Blood Bank, Mecca, Saudi Arabia

[19] Al Faisal Univ, Coll Med, Riyadh, Saudi Arabia

[20] King Faisal Specialist Hosp & Res Ctr, Res Ctr, Jeddah, Saudi Arabia

[21] King Saud Bin Abdulaziz Univ Hlth Sci, Coll Sci & Hlth Profess, Basic Sci Dept, Natl Guard Hlth Affairs, Jeddah, Saudi Arabia

[22] Batterjee Med Coll, Dept Pharmaceut Sci, Pharm Program, Jeddah, Saudi Arabia

[23] Suez Canal Univ, Fac Vet Med, Pharmacol Dept, Ismailia, Egypt

来源：

FRONTIERS IN PHARMACOLOGY | 2022年 / 13卷

关键词：

asthma; dupilumab; monoclonal antibody; systematic review; meta-analysis; TO-SEVERE ASTHMA; PERSISTENT ASTHMA; CHILDHOOD ASTHMA; CHILDREN;

D O I：

10.3389/fphar.2022.992731

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Background: Dupilumab is a human monoclonal antibody directed against the alpha subunit of the interleukin-4 receptor and inhibits the signaling of IL-4 and IL-13. It is approved for treating asthma and other type-2 inflammatory diseases. There is a conflict in the literature regarding the safety and efficacy of dupilumab. Thus, we aimed to assess the safety and efficacy of dupilumab in patients with moderate to severe asthma. Methods: Six databases (PubMed, Embase, Scopus, Web of Science, Cochrane library, and registry) were searched until January 2022. We included randomized controlled trials that compared dupilumab with the placebo in moderate to severe asthma patients. We extracted the data at 12 and 24 weeks and analyzed them using review manager 5.4. Findings: Thirteen trials were included. Dupilumab significantly improved the forced expiratory volume in 1 s, asthma control questionnaire score, the fraction of exhaled nitric oxide level, and immunoglobulin E level at 12 and 24 weeks (p < 0.05). However, it was associated with increased blood eosinophils at 12 and 24 weeks. Dupilumab was generally a safe agent for asthmatic patients. It showed no significant difference compared with the placebo regarding most adverse events. Conclusion: Dupilumab improves pulmonary function and reduces local and systemic inflammatory markers with minimal adverse events in patients with moderate to severe asthma.

引用

页数：16

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