Fish Oil Enriched Intravenous Lipid Emulsions Reduce Triglyceride Levels in Non-Critically Ill Patients with TPN and Type 2 Diabetes. A Post-Hoc Analysis of the INSUPAR Study

被引：4

作者：

Abuin-Fernandez, Jose ^{[1
,2
]}

Jose Tapia-Guerrero, Maria ^{[1
]}

Lopez-Urdiales, Rafael ^{[3
]}

Herranz-Antolin, Sandra ^{[4
]}

Manuel Garcia-Almeida, Jose ^{[5
]}

Garcia-Malpartida, Katherine ^{[6
]}

Ferrer-Gomez, Mercedes ^{[7
]}

Cancer-Minchot, Emilia ^{[8
]}

Miguel Luengo-Perez, Luis ^{[9
]}

Alvarez-Hernandez, Julia ^{[10
]}

Aragon Valera, Carmen ^{[11
]}

Ocon-Breton, Julia ^{[12
]}

Garcia-Manzanares, Alvaro ^{[13
]}

Breton-Lesmes, Irene ^{[14
]}

Serrano-Aguayo, Pilar ^{[15
]}

Perez-Ferre, Natalia ^{[16
]}

Jose Lopez-Gomez, Juan ^{[17
]}

Olivares-Alcolea, Josefina ^{[18
]}

Arraiza-Irigoyen, Carmen ^{[19
]}

Tejera-Perez, Cristina ^{[20
]}

Daniel Martinez-Gonzalez, Jorge ^{[21
]}

Urioste-Fondo, Ana ^{[22
]}

Luis Abad-Gonzalez, Angel ^{[23
]}

Jose Molina-Puerta, Maria ^{[24
]}

Zugasti-Murillo, Ana ^{[25
]}

Parra-Barona, Juan ^{[26
]}

Lopez-Cobo, Irela ^{[27
]}

Olveira, Gabriel ^{[1
,2
,28
]}

机构：

[1] Hosp Reg Univ Malaga, Inst Invest Biomed Malaga IBIMA, Unidad Gest Clin Endocrinol & Nutr, Malaga 29010, Spain

[2] Univ Malaga, Dept Med & Dermatol, Malaga 29071, Spain

[3] Hosp Univ Bellvitge, Serv Endocrinol & Nutr, Lhospitalet De Llobregat 08907, Barcelona, Spain

[4] Hosp Univ Guadalajara, Serv Endocrinol & Nutr, Guadalajara 19002, Spain

[5] Hosp Univ Virgen de la Victoria, Serv Endocrinol & Nutr, Malaga 29010, Spain

[6] Hosp Univ & Politecn La Fe, Serv Endocrinol & Nutr, Valencia 46026, Spain

[7] Hosp Clin Univ Virgen de la Arrixaca, Serv Endocrinol & Nutr, Murcia 30120, Spain

[8] Hosp Univ Fuenlabrada, Secc Endocrinol & Nutr, Madrid 28942, Spain

[9] Hosp Univ Badajoz, Serv Endocrinol & Nutr, Badajoz 06080, Spain

[10] Hosp Univ Principe Asturias, Serv Endocrinol & Nutr, Madrid 28805, Spain

[11] Hosp Univ Fdn Jimenez Diaz, Serv Endocrinol & Nutr, Madrid 28040, Spain

[12] Hosp Univ Lozano Blesa, Serv Endocrinol & Nutr, Zaragoza 50009, Spain

[13] Hosp Gen La Mancha Ctr, Serv Endocrinol & Nutr, Alcazar De San Juan 13600, Spain

[14] Hosp Univ Gregorio Maranon, Serv Endocrinol & Nutr, Madrid 28007, Spain

[15] Hosp Univ Virgen del Rocio, Unidad Endocrinol & Nutr, Seville 41013, Spain

[16] Hosp Clin San Carlos, Serv Endocrinol & Nutr, Madrid 28040, Spain

[17] Hosp Clin Univ Valladolid, Serv Endocrinol & Nutr, Valladolid 47005, Spain

[18] Hosp Univ Son Llatzer, Serv Endocrinol & Nutr, Illes Balears 07198, Spain

[19] Complejo Hosp Jaen, Serv Endocrinol & Nutr, Jaen 23007, Spain

[20] Complejo Hosp Univ Ferrol, Serv Endocrinol & Nutr, La Coruna 15045, Spain

[21] Hosp Univ Severo Ochoa, Serv Endocrinol & Nutr, Leganes 28914, Madrid, Spain

[22] Complejo Asistencial Univ Leon, Serv Endocrinol & Nutr, Leon 24071, Spain

[23] Hosp Gen Univ Alicante, Secc Endocrinol, Unidad Nutr, Alicante 03010, Spain

[24] Hosp Univ Reina Sofia, Serv Endocrinol & Nutr, Cordoba 14004, Spain

[25] Complejo Hosp Navarra, Serv Endocrinol & Nutr, Navarra 31008, Spain

[26] Hosp Merida, Serv Endocrinol & Nutr, Badajoz 06800, Spain

[27] Hosp St Joan Despi Moises Broggi, Serv Endocrinol & Nutr, Barcelona 08970, Spain

[28] Inst Salud Carlos III, CIBERDEM CB07 08 0019, Madrid 28029, Spain

来源：

NUTRIENTS | 2020年 / 12卷 / 06期

关键词：

parenteral nutrition; type 2 diabetes mellitus; polyunsaturated fatty acids; omega; 3; hospital; LIVER-FUNCTION TESTS; PARENTERAL-NUTRITION; CLINICAL-OUTCOMES; SUPPLEMENTATION; METAANALYSIS; IMPACT;

D O I：

10.3390/nu12061566

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

There are no studies that have specifically assessed the role of intravenous lipid emulsions (ILE) enriched with fish oil in people with diabetes receiving total parenteral nutrition (TPN). The objective of this study was to assess the metabolic control (glycemic and lipid) and in-hospital complications that occurred in non-critically ill inpatients with TPN and type 2 diabetes with regard to the use of fish oil emulsions compared with other ILEs. We performed a post-hoc analysis of the Insulin in Parenteral Nutrition (INSUPAR) trial that included patients who started with TPN for any cause and that would predictably continue with TPN for at least five days. The study included 161 patients who started with TPN for any cause. There were 80 patients (49.7%) on fish oil enriched ILEs and 81 patients (50.3%) on other ILEs. We found significant decreases in triglyceride levels in the fish oil group compared to the other patients. We did not find any differences in glucose metabolic control: mean capillary glucose, glycemic variability, and insulin dose, except in the number of mild hypoglycemic events that was significantly higher in the fish oil group. We did not observe any differences in other metabolic, liver or infectious complications, in-hospital length of stay or mortality.

引用

页数：11