Characterization of a 3D optrode array for infrared neural stimulation

被引:39
|
作者
Abaya, T. V. F. [1 ]
Diwekar, M. [1 ]
Blair, S. [1 ,2 ]
Tathireddy, P. [1 ]
Rieth, L. [1 ]
Clark, G. A. [2 ]
Solzbacher, F. [1 ,2 ]
机构
[1] Univ Utah, Dept Elect & Comp Engn, Salt Lake City, UT 84112 USA
[2] Univ Utah, Dept Bioengn, Salt Lake City, UT 84112 USA
来源
BIOMEDICAL OPTICS EXPRESS | 2012年 / 3卷 / 09期
关键词
LASER NERVE-STIMULATION; CAT SCIATIC-NERVE; IN-VIVO; WAVE-GUIDES; OPTICAL STIMULATION; PERIPHERAL-NERVE; LIGHT; CIRCUITRY;
D O I
10.1364/BOE.3.002200
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
This paper characterizes the Utah Slant Optrode Array (USOA) as a means to deliver infrared light deep into tissue. An undoped crystalline silicon (100) substrate was used to fabricate 10 x 10 arrays of optrodes with rows of varying lengths from 0.5 mm to 1.5 mm on a 400-mu m pitch. Light delivery from optical fibers and loss mechanisms through these Si optrodes were characterized, with the primary loss mechanisms being Fresnel reflection, coupling, radiation losses from the tapered shank and total internal reflection in the tips. Transmission at the optrode tips with different optical fiber core diameters and light in-coupling interfaces was investigated. At lambda = 1.55 mu m, the highest optrode transmittance of 34.7%, relative to the optical fiber output power, was obtained with a 50-mu m multi-mode fiber butt-coupled to the optrode through an intervening medium of index n = 1.66. Maximum power is directed into the optrodes when using fibers with core diameters of 200 mu m or less. In addition, the output power varied with the optrode length/taper such that longer and less tapered optrodes exhibited higher light transmission efficiency. Output beam profiles and potential impacts on physiological tests were also examined. Future work is expected to improve USOA efficiency to greater than 64%. (c) 2012 Optical Society of America
引用
收藏
页码:2200 / 2219
页数:20
相关论文
共 50 条
  • [1] A 3D glass optrode array for optical neural stimulation
    Abaya, T. V. F.
    Blair, S.
    Tathireddy, P.
    Rieth, L.
    Solzbacher, F.
    BIOMEDICAL OPTICS EXPRESS, 2012, 3 (12):
  • [2] Optical Characterization of the Utah Slant Optrode Array for Intrafascicular Infrared Neural Stimulation
    Abaya, T. V. F.
    Diwekar, M.
    Blair, S.
    Tathireddy, P.
    Rieth, L.
    Clark, G. A.
    Solzbacher, F.
    PHOTONIC THERAPEUTICS AND DIAGNOSTICS VIII, PTS 1 AND 2, 2012, 8207
  • [3] Optrode Arrays for Infrared Neural Stimulation
    Abaya, T. V. F.
    Diwekar, M.
    Blair, S.
    Tathireddy, P.
    Rieth, L.
    Clark, G. A.
    Solzbacher, F.
    PHOTONIC THERAPEUTICS AND DIAGNOSTICS IX, 2013, 8565
  • [4] Optimization of an optrode microdevice for infrared neural stimulation
    Boros, O. C.
    Horvath, A. C.
    Beleznai, S.
    Sepsi, O.
    Csosz, D.
    Fekete, Z.
    Koppa, P.
    APPLIED OPTICS, 2019, 58 (14) : 3870 - 3876
  • [5] Optical characterization of an infrared neural optrode
    Horvath, Agoston Csaba
    Boros, Csanad Ors
    Sepsi, Ors
    Beleznai, Szabolcs
    Koppa, Pal
    Fekete, Zoltan
    2018 SYMPOSIUM ON DESIGN, TEST, INTEGRATION & PACKAGING OF MEMS AND MOEMS (DTIP), 2018,
  • [6] Optical and thermal modeling of an optrode microdevice for infrared neural stimulation
    Boros, O. C.
    Horvath, A. C.
    Beleznai, S.
    Sepsi, O.
    Lenk, S.
    Fekete, Z.
    Koppa, P.
    APPLIED OPTICS, 2018, 57 (24) : 6952 - 6957
  • [7] Heterogeneous 3D Optrode with Variable Spatial Resolution for Optogenetic Stimulation and Electrophysiological Recording
    Ayub, Suleman
    Barz, Falk
    Paul, Oliver
    Ruther, Patrick
    2016 38TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC), 2016, : 1762 - 1765
  • [8] Smart Optrode for Neural Stimulation and Sensing
    Dehkhoda, F.
    Soltan, A.
    Ramezani, R.
    Zhao, H.
    Liu, Y.
    Constandinou, T.
    Degenaar, P.
    2015 IEEE SENSORS, 2015, : 1965 - 1968
  • [9] 3D Diamond Electrode Array for High-Acuity Stimulation in Neural Tissue
    Stamp, Melanie E. M.
    Tong, Wei
    Ganesan, Kumaravelu
    Prawer, Steven
    Ibbotson, Michael R.
    Garrett, David J.
    ACS APPLIED BIO MATERIALS, 2020, 3 (03) : 1544 - 1552
  • [10] Multisite microLED optrode array for neural interfacing
    McAlinden N.
    Cheng Y.
    Scharf R.
    Xie E.
    Gu E.
    Reiche C.F.
    Sharma R.
    Tathireddy P.
    Dawson M.D.
    Rieth L.
    Blair S.
    Mathieson K.
    Neurophotonics, 2019, 6 (03)