Contrasting influences of glucuronidation and O-methylation of epicatechin on hydrogen peroxide-induced cell death in neurons and fibroblasts

被引：128
作者：
Spencer, JPE
Schroeter, H
Crossthwaithe, AJ
Kuhnle, G
Williams, RJ
Rice-Evans, C
机构：
[1] Kings Coll London, GKT Sch Biomed Sci, Wolfson Ctr Age Related Dis, Antioxidant Res Grp, London SE1 9RT, England
[2] Kings Coll London, GKT Sch Biomed Sci, Ctr Res Neurosci, London SE1 9RT, England
来源：
FREE RADICAL BIOLOGY AND MEDICINE | 2001年 / 31卷 / 09期
基金：
英国生物技术与生命科学研究理事会;
关键词：
flavonoid; epicatechin glucuronide; 3 '-O-methyl epicatechin; uptake; bioactivity; oxidative stress; neuron; fibroblast; free radicals;
D O I：
10.1016/S0891-5849(01)00704-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The purpose of this study was to examine the comparative mechanisms by which the dietary form of the flavonoid epicatechin and its predominant in vivo metabolite, epicatechin glucuronide, influence oxidative stress-induced cell death in fibroblasts and neurons. The results demonstrate the contrasting influences of in vivo glucuronidation and methylation on the bioactivity of epicatechin. (C) 2001 Elsevier Science Inc.
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收藏
页码：1139 / 1146
页数：8
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