RLIP76 and cancer

被引：72
作者：
Awasthi, Sanjay [2 ]
Singhal, Sharad S. [2 ]
Awasthi, Yogesh C. [2 ]
Martin, Bryan [1 ]
Woo, Jung-Hee [1 ]
Cunningham, C. Casey [3 ]
Frankel, Arthur E. [1 ]
机构：
[1] Scott & White Hosp, Canc Res Inst, Temple, TX 76502 USA
[2] Univ N Texas, Hlth Sci Ctr, Dept Mol Biol & Immunol, Ft Worth, TX USA
[3] Terapio Inc, Austin, TX USA
来源：
CLINICAL CANCER RESEARCH | 2008年 / 14卷 / 14期
关键词：
D O I：
10.1158/1078-0432.CCR-08-0145
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
RLIP76 is a multifunctional membrane protein that transports glutathione conjugates of electrophilic compounds and other xenobiotics including chemotherapy agents out of cells. The protein is overexpressed in lung carcinomas, ovarian carcinomas, and melanomas. The protein also binds Ral and participates in mitotic spindle function, clathrin-dependent endocytosis, and triggers GTPase-activating protein activity. It is found throughout the cell, in membrane, cytosol, and the nucleus, and is known to shift between these compartments in response to stress. Loss of RLIP76 by antibody or antisense therapy is associated with increased sensitivity to radiation and chemotherapy. Conversely, liposomally delivered R LIP may treat poisoning and wounds.
引用
收藏
页码：4372 / 4377
页数：6
相关论文
共 51 条
[1]   Novel function of human RLIP76: ATP-dependent transport of glutathione conjugates and doxorubicin [J].
Awasthi, S ;
Cheng, JZ ;
Singhal, SS ;
Saini, MK ;
Pandya, U ;
Pikula, S ;
Bandorowicz-Pikula, J ;
Singh, SV ;
Zimniak, P ;
Awasthi, YC .
BIOCHEMISTRY, 2000, 39 (31) :9327-9334
[2]   ATP-Dependent colchicine transport by human erythrocyte glutathione conjugate transporter [J].
Awasthi, S ;
Singhal, SS ;
Pandya, U ;
Gopal, S ;
Zimniak, P ;
Singh, SV ;
Awasthi, YC .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 1999, 155 (03) :215-226
[3]   ADENOSINE TRIPHOSPHATE-DEPENDENT TRANSPORT OF DOXORUBICIN, DAUNOMYCIN, AND VINBLASTINE IN HUMAN TISSUES BY A MECHANISM DISTINCT FROM THE P-GLYCOPROTEIN [J].
AWASTHI, S ;
SINGHAL, SS ;
SRIVASTAVA, SK ;
ZIMNIAK, P ;
BAJPAI, KK ;
SAXENA, M ;
SHARMA, R ;
ZILLER, SA ;
FRENKEL, EP ;
SINGH, SV ;
HE, NG ;
AWASTHI, YC .
JOURNAL OF CLINICAL INVESTIGATION, 1994, 93 (03) :958-965
[4]   ATP-dependent human erythrocyte glutathione-conjugate transporter. II. Functional reconstitution of transport activity [J].
Awasthi, S ;
Singhal, SS ;
Pikula, S ;
Piper, JT ;
Srivastava, SK ;
Torman, RT ;
Bandorowicz-Pikula, J ;
Lin, JT ;
Singh, SV ;
Zimniak, P ;
Awasthi, YC .
BIOCHEMISTRY, 1998, 37 (15) :5239-5248
[5]   ATP-dependent human erythrocyte glutathione-conjugate transporter. I. Purification, photoaffinity labeling, and kinetic characteristics of ATPase activity [J].
Awasthi, S ;
Singhal, SS ;
Srivastava, SK ;
Torman, RT ;
Zimniak, P ;
Bandorowicz-Pikula, J ;
Singh, SV ;
Piper, JT ;
Awasthi, YC ;
Pikula, S .
BIOCHEMISTRY, 1998, 37 (15) :5231-5238
[6]   RLIP76, a non-ABC transporter, and drug resistance in epilepsy [J].
Awasthi, S ;
Hallene, KL ;
Fazio, V ;
Singhal, SS ;
Cucullo, L ;
Awasthi, YC ;
Dini, G ;
Janigro, D .
BMC NEUROSCIENCE, 2005, 6 (1)
[7]   RLIP76 is a major determinant of radiation sensitivity [J].
Awasthi, S ;
Singhal, SS ;
Yadav, S ;
Singhal, J ;
Drake, K ;
Nadkar, A ;
Zajac, E ;
Wickramarachchi, D ;
Rowe, N ;
Yacoub, A ;
Boor, P ;
Dwivedi, S ;
Dent, P ;
Jarman, WE ;
John, B ;
Awasthi, YC .
CANCER RESEARCH, 2005, 65 (14) :6022-6028
[8]   Transport of glutathione conjugates and chemotherapeutic drugs by RLIP76 (RALBP1): A novel link between G-protein and tyrosine kinase signaling and drug resistance [J].
Awasthi, S ;
Singhal, SS ;
Sharma, R ;
Zimniak, P ;
Awasthi, YC .
INTERNATIONAL JOURNAL OF CANCER, 2003, 106 (05) :635-646
[9]  
Awasthi S, 2003, INT J ONCOL, V22, P721
[10]   Functional reassembly of ATP-dependent xenobiotic transport by the N- and C-terminal domains of RLIP76 and identification of ATP binding sequences [J].
Awasthi, S ;
Cheng, JZ ;
Singhal, SS ;
Pandya, U ;
Sharma, R ;
Singh, SV ;
Zimniak, P ;
Awasthi, YC .
BIOCHEMISTRY, 2001, 40 (13) :4159-4168
123456