Anti-depression effects of Danggui-Shaoyao-San, a fixed combination of Traditional Chinese Medicine, on depression model in mice and rats

被引：46

作者：

Xu, Fan ^{[1
,2
,3
]}

Peng, Daiyin ^{[2
,3
]}

Tao, Chunlei ^{[2
,3
]}

Yin, Dengke ^{[2
,3
]}

Kou, Junping ^{[1
]}

Zhu, Danni ^{[1
]}

Yu, Boyang ^{[1
]}

机构：

[1] China Pharmaceut Univ, Dept Chinese Compound Prescript, Nanjing 210038, Jiangsu, Peoples R China

[2] Anhui Prov Key Lab Chinese Med Res & Dev, Hefei 230038, Anhui, Peoples R China

[3] Anhui Univ Tradit Chinese Med, Sch Pharm, Hefei 230031, Anhui, Peoples R China

来源：

PHYTOMEDICINE | 2011年 / 18卷 / 13期

关键词：

Danggui-Shaoyao-San; A fixed combination; Anti-depression; Arginine vasopressin; TOKI-SHAKUYAKU-SAN; HERBAL MEDICINE; MILD STRESS; VASOPRESSINERGIC SYSTEM; PARAVENTRICULAR NUCLEUS; EXPRESSING NEURONS; HIGH ANXIETY; ANTIDEPRESSANT; PLASMA; WOMEN;

D O I：

10.1016/j.phymed.2011.05.002

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Anti-depression effects of Danggui-Shaoyao-San (DSS, 1.8-7.2 g/kg, orally), a famous Chinese compound prescription with a fixed combination, on forced swimming test (FST) and chronic unpredictable mild stress (CUMS) model were investigated. DSS (7.2 g/kg, orally, 7 days) shortened immobility time in FST model and DSS (3.6 or 7.2 g/kg, orally, 21 days) increased the open-field activities and the percentage of sugar preference in CUMS model. DSS (7.2 g/kg, orally, 21 days) also decreased the content of arginine vasopressin (AVP) in the pituitary and the expression of AVP mRNA in hypothalamus compared with the stress control group. These results demonstrated for the first time DSS has anti-depression effect and it may be influencing the central AVP system. (C) 2011 Elsevier GmbH. All rights reserved.

引用

页码：1130 / 1136

页数：7

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