Biodegradable xylitol-based polymers

被引：100
作者：
Bruggeman, Joost P. [1 ,2 ]
Bettinger, Christopher J. [3 ]
Nijst, Christiaan L. E. [1 ]
Kohane, Daniel S. [4 ]
Langer, Robert [1 ]
机构：
[1] MIT, Dept Chem Engn, Cambridge, MA 02139 USA
[2] Erasmus Univ, Erasmus Med Ctr, Dept Plast & Reconstruct Surg, NL-3015 CE Rotterdam, Netherlands
[3] MIT, Dept Mat Sci & Engn, Cambridge, MA 02139 USA
[4] Harvard Univ, Sch Med, Childrens Hosp, Dept Anaesthesiol, Boston, MA 02114 USA
来源：
ADVANCED MATERIALS | 2008年 / 20卷 / 10期
关键词：
D O I：
10.1002/adma.200702377
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Synthetic polymers composed or metabolites endogenous to the mammalian organism are designed. The design is based on the monomer xylitol, which possesses a wide range of physical properties that are biologically relevant. Xylitol-based hydrogels and elastomers are biocompatible in vitro and in vivo, compared to the prevalent synthetic polymer poly (L-lactic-co-glycolic acid) (PLGA). It furthermore provides a platform to tune mechanical properties, degradation profiles, and cell attachment.
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页码：1922 / +
页数：7
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