Biodegradable xylitol-based polymers

被引：101

作者：

Bruggeman, Joost P. ^{[1
,2
]}

Bettinger, Christopher J. ^{[3
]}

Nijst, Christiaan L. E. ^{[1
]}

Kohane, Daniel S. ^{[4
]}

Langer, Robert ^{[1
]}

机构：

[1] MIT, Dept Chem Engn, Cambridge, MA 02139 USA

[2] Erasmus Univ, Erasmus Med Ctr, Dept Plast & Reconstruct Surg, NL-3015 CE Rotterdam, Netherlands

[3] MIT, Dept Mat Sci & Engn, Cambridge, MA 02139 USA

[4] Harvard Univ, Sch Med, Childrens Hosp, Dept Anaesthesiol, Boston, MA 02114 USA

来源：

ADVANCED MATERIALS | 2008年 / 20卷 / 10期

关键词：

D O I：

10.1002/adma.200702377

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Synthetic polymers composed or metabolites endogenous to the mammalian organism are designed. The design is based on the monomer xylitol, which possesses a wide range of physical properties that are biologically relevant. Xylitol-based hydrogels and elastomers are biocompatible in vitro and in vivo, compared to the prevalent synthetic polymer poly (L-lactic-co-glycolic acid) (PLGA). It furthermore provides a platform to tune mechanical properties, degradation profiles, and cell attachment.

引用

页码：1922 / +

页数：7

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