Biodegradable xylitol-based polymers

被引：101

作者：

Bruggeman, Joost P. ^{[1
,2
]}

Bettinger, Christopher J. ^{[3
]}

Nijst, Christiaan L. E. ^{[1
]}

Kohane, Daniel S. ^{[4
]}

Langer, Robert ^{[1
]}

机构：

[1] MIT, Dept Chem Engn, Cambridge, MA 02139 USA

[2] Erasmus Univ, Erasmus Med Ctr, Dept Plast & Reconstruct Surg, NL-3015 CE Rotterdam, Netherlands

[3] MIT, Dept Mat Sci & Engn, Cambridge, MA 02139 USA

[4] Harvard Univ, Sch Med, Childrens Hosp, Dept Anaesthesiol, Boston, MA 02114 USA

来源：

ADVANCED MATERIALS | 2008年 / 20卷 / 10期

关键词：

D O I：

10.1002/adma.200702377

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Synthetic polymers composed or metabolites endogenous to the mammalian organism are designed. The design is based on the monomer xylitol, which possesses a wide range of physical properties that are biologically relevant. Xylitol-based hydrogels and elastomers are biocompatible in vitro and in vivo, compared to the prevalent synthetic polymer poly (L-lactic-co-glycolic acid) (PLGA). It furthermore provides a platform to tune mechanical properties, degradation profiles, and cell attachment.

引用

页码：1922 / +

页数：7

共 28 条

[1] Mechanical properties of acellular peripheral nerve [J].

Borschel, GH ;

Kia, KF ;

Kuzon, WM ;

Dennis, RG .

JOURNAL OF SURGICAL RESEARCH, 2003, 114 (02) :133-139

[2] Controlled degradation and mechanical behavior of photopolymerized hyaluronic acid networks [J].

Burdick, JA ;

Chung, C ;

Jia, XQ ;

Randolph, MA ;

Langer, R .

BIOMACROMOLECULES, 2005, 6 (01) :386-391

[3] Tissue engineering of arteries by directed remodeling of intact arterial segments [J].

Clerin, V ;

Nichol, JW ;

Petko, M ;

Myung, RJ ;

Gaynor, JW ;

Gooch, KJ .

TISSUE ENGINEERING, 2003, 9 (03) :461-472

[4] Safety assessment of inhaled xylitol in subjects with cystic fibrosis [J].

Durairaj, Lakshmi ;

Launspach, Janice ;

Watt, Janet L. ;

Mohamad, Zeinab ;

Kline, Joel ;

Zabner, Joseph .

JOURNAL OF CYSTIC FIBROSIS, 2007, 6 (01) :31-34

[5]

ELLINGSWORTH LR, 1986, J IMMUNOL, V136, P877

[6]

Flory P. J., 1953, PRINCIPALS POLYM CHE

[7] Synthesis and characterization of linear polyamides derived from L-arabinitol and xylitol [J].

García-Martín, MDG ;

Hernández, EB ;

Pérez, RR ;

Alla, A ;

Muñoz-Guerra, S ;

Galbis, JA .

MACROMOLECULES, 2004, 37 (15) :5550-5556

[8] Preparation and crystallization kinetics of new structurally well-defined star-shaped biodegradable poly(L-lactide)s initiated with diverse natural sugar alcohols [J].

Hao, QH ;

Li, FX ;

Li, QB ;

Li, Y ;

Jia, L ;

Yang, J ;

Fang, Q ;

Cao, AM .

BIOMACROMOLECULES, 2005, 6 (04) :2236-2247

[9]

Hern DL, 1998, J BIOMED MATER RES, V39, P266, DOI 10.1002/(SICI)1097-4636(199802)39:2<266::AID-JBM14>3.0.CO

[10]

2-B

← 1 2 3 →