Atrial remodeling in atrial fibrillation and association between microRNA network and atrial fibrillation

被引：21
作者：
Zhang Ying [1 ]
Dong DeLi [1 ]
Yang BaoFeng [1 ]
机构：
[1] Minist Educ, Dept Pharmacol, State Prov Key Labs Biomed Pharmaceut China, Key Lab Cardiovasc Res, Harbin 150086, Peoples R China
来源：
SCIENCE CHINA-LIFE SCIENCES | 2011年 / 54卷 / 12期
基金：
中国国家自然科学基金;
关键词：
atrial fibrillation; remodeling; microRNA; EXPRESSION; MODEL; CONTRIBUTES; DYSFUNCTION; PERSISTENT; CHANNELS; MIR-133; DOGS; RNA;
D O I：
10.1007/s11427-011-4241-3
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Atrial fibrillation (AF) remains one of the leading causes of morbidity and mortality in the world which are related to palpitations, fainting, congestive heart failure or stroke. The mechanism for atrial fibrillation has been identified as electrical remodeling, structure remodeling and intracellular calcium handling remodeling. microRNAs (miRNAs) have recently emerged as one of the important factors in regulating gene expression. So far, thousands of miRNA genes have been found in diverse animals with the function of regulating cell death, cell proliferation, haematopoiesis and even participate in the processing of cardiovascular disease. In this review, we summarize the mechanism of AF and the association of microRNAs network with AF. We provide a potential perspective of miRNAs as the therapeutic target for AF.
引用
收藏
页码：1097 / 1102
页数：6
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