Discovery of estrogen receptor α modulators from natural compounds in Si-Wu-Tang series decoctions using estrogen-responsive MCF-7 breast cancer cells

被引：25

作者：

Liu, Li ^{[1
]}

Ma, Hongyue ^{[1
]}

Tang, Yuping ^{[1
]}

Chen, Wenxing ^{[1
]}

Lu, Yin ^{[1
]}

Guo, Jianming ^{[1
]}

Duan, Jin-ao ^{[1
]}

机构：

[1] Nanjing Univ Chinese Med, Jiangsu Key Lab TCM Formulae Res, Nanjing 210046, Jiangsu, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2012年 / 22卷 / 01期

基金：

中国国家自然科学基金;

关键词：

SERMs; Si-Wu-Tang series decoctions; FlexX-Pharm;

D O I：

10.1016/j.bmcl.2011.11.041

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The binding between the estrogen receptor alpha (ER-alpha) and a variety of compounds in traditional Chinese formulae, Si-Wu-Tang (SWT) series decoctions, was studied using a stably-transfected human breast cancer cell line (MVLN). In 38 compounds tested from SWT series decoctions, the estrogen-like activity of 22 compounds was above 60% in 20 mu gmL (1). Furthermore, theoretical affinity of these compounds was certificated using the functional virtual screen of ER-alpha modulators by FlexX-Pharm. The accuracy of functional virtual screening of ER-alpha modulators could reach to 77.27%. The results showed that some compounds, such as organic acids and flavones in SWT series decoctions could be used as selective estrogen receptor modulators (SERMs) and could be selected for further development as potential agents for estrogen related diseases. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：154 / 163

页数：10

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