Developing Mn-doped lead sulfide quantum dots for MRI labels

被引：9

作者：

Turyanska, Lyudmila ^{[1
,2
]}

Moro, Fabrizio ^{[1
]}

Patane, Amalia ^{[1
]}

Barr, James ^{[1
]}

Kockenberger, Walter ^{[1
]}

Taylor, Alexander ^{[3
]}

Faas, Henryk M. ^{[3
]}

Fowler, Maxine ^{[3
]}

Wigmore, Peter ^{[3
]}

Trueman, Rebecca C. ^{[3
]}

Williams, Huw E. L. ^{[4
]}

Thomas, Neil R. ^{[4
]}

机构：

[1] Univ Nottingham, Sch Phys & Astron, Nottingham NG7 2RD, England

[2] Lincoln Univ, Sch Chem, Lincoln LN6 7TS, England

[3] Univ Nottingham, Fac Med & Hlth Sci, Nottingham NG7 2RD, England

[4] Univ Nottingham, Sch Chem, Ctr Biomol Sci, Nottingham NG7 2RD, England

来源：

JOURNAL OF MATERIALS CHEMISTRY B | 2016年 / 4卷 / 42期

基金：

英国工程与自然科学研究理事会; 英国国家替代、减少和改良动物研究中心;

关键词：

MAGNETIC-RESONANCE; IN-VIVO; COLLOIDAL NANOCRYSTALS; COMPUTED-TOMOGRAPHY; CONTRAST AGENTS; NANOPARTICLES; CELLS; FLUORESCENT; PROBES; RELAXIVITY;

D O I：

10.1039/c6tb02574a

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Magnetic interactions of Mn2+ ions in lead sulfide (PbS) nanocrystals with protons in water are probed by NMR and MRI. A thin layer of capping molecules enables free solvent diffusion to the nanocrystal surface resulting in a decrease of proton relaxation times. Magnetic resonance imaging of neuronal cell pellets exposed to (PbMn)S at non-toxic concentrations demonstrates their prospects as MRI-labels.

引用

页码：6797 / 6802

页数：6

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