The novel tellurium immunomodulator AS101 inhibits interleukin-10 production and p38 MAPK expression in atopic dermatitis

被引：15

作者：

Sredni-Kenigsbuch, Dvora ^{[1
]}

Shohat, Michael ^{[2
]}

Shohat, Batia ^{[3
]}

Ben-Amitai, Dan ^{[4
]}

Chan, Chi-Chao ^{[5
]}

David, Michael ^{[2
]}

机构：

[1] Bar Ilan Univ, Interdisciplinary Dept, IL-52900 Ramat Gan, Israel

[2] Schneider Childrens Hosp, Rabin Med Ctr, Dept Dermatol, Petah Tiqwa, Israel

[3] Schneider Childrens Hosp, Rabin Med Ctr, Cellular Immunol Unit, Petah Tiqwa, Israel

[4] Schneider Childrens Hosp, Rabin Med Ctr, Pediat Dermatol Unit, Petah Tiqwa, Israel

[5] NEI, NIH, Immunol Lab, Bethesda, MD 20892 USA

来源：

JOURNAL OF DERMATOLOGICAL SCIENCE | 2008年 / 50卷 / 03期

关键词：

D O I：

10.1016/j.jdermsci.2007.12.007

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The immunomodulator, AS101, inhibits production of IL-10, IL-4 and expression of p38 MAPK, while increasing production of IFN-gamma and IL-2. Together with its excellent clinical safety profile in humans, suggests a potential therapeutic use for AD. (c) 2008 Japanese Society for Investigative Dermatology. Published by Elsevier Ireland Ltd. All rights reserved.

引用

页码：232 / 235

页数：4

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