The novel tellurium immunomodulator AS101 inhibits interleukin-10 production and p38 MAPK expression in atopic dermatitis

被引：15
作者：
Sredni-Kenigsbuch, Dvora [1 ]
Shohat, Michael [2 ]
Shohat, Batia [3 ]
Ben-Amitai, Dan [4 ]
Chan, Chi-Chao [5 ]
David, Michael [2 ]
机构：
[1] Bar Ilan Univ, Interdisciplinary Dept, IL-52900 Ramat Gan, Israel
[2] Schneider Childrens Hosp, Rabin Med Ctr, Dept Dermatol, Petah Tiqwa, Israel
[3] Schneider Childrens Hosp, Rabin Med Ctr, Cellular Immunol Unit, Petah Tiqwa, Israel
[4] Schneider Childrens Hosp, Rabin Med Ctr, Pediat Dermatol Unit, Petah Tiqwa, Israel
[5] NEI, NIH, Immunol Lab, Bethesda, MD 20892 USA
来源：
JOURNAL OF DERMATOLOGICAL SCIENCE | 2008年 / 50卷 / 03期
关键词：
D O I：
10.1016/j.jdermsci.2007.12.007
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
The immunomodulator, AS101, inhibits production of IL-10, IL-4 and expression of p38 MAPK, while increasing production of IFN-gamma and IL-2. Together with its excellent clinical safety profile in humans, suggests a potential therapeutic use for AD. (c) 2008 Japanese Society for Investigative Dermatology. Published by Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：232 / 235
页数：4
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