The isolation, structure determination and cytotoxicity of the new fungal metabolite, trichodermamide C

被引：41

作者：

Davis, Rohan A. ^{[1
]}

Longden, James ^{[1
]}

Avery, Vicky M. ^{[1
]}

Healy, Peter C. ^{[1
]}

机构：

[1] Griffith Univ, Eskitis Inst Cell & Mol Therapies, Brisbane, Qld 4111, Australia

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 09期

关键词：

trichodermamide C; X-ray structure; cytotoxicity; high content screening; A549; HCT116;

D O I：

10.1016/j.bmcl.2008.03.090

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Chemical investigations of a culture broth from the endophytic fungus Eupenicillium sp. afforded the new modified dipeptide trichodermamide C 1. The structure of 1 was established following the analysis of NMR, UV, IR, MS and X-ray diffraction data. Trichodermamide C was shown by high content screening to display cytotoxicity towards the human colorectal carcinoma HCT116 and human lung carcinoma A549 with IC50 values of 0.68 and 4.28 mu g/ml, respectively. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：2836 / 2839

页数：4

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